Department of Breast Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China.
Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, China.
Front Immunol. 2024 Aug 12;15:1452303. doi: 10.3389/fimmu.2024.1452303. eCollection 2024.
While breast cancer treatments have advanced significantly nowadays, yet metastatic, especially triple-negative breast cancer (TNBC), remains challenging with low survival. Cancer immunotherapy, a promising approach for HER2-positive and TNBC, still faces resistance hurdles. Recently, numerous studies have set their sights on the resistance of immunotherapy for breast cancer. Our study provides a thorough comprehension of the current research landscape, hotspots, and emerging breakthroughs in this critical area through a meticulous bibliometric analysis. As of March 26, 2024, a total of 1341 articles on immunology resistance in breast cancer have been gathered from Web of Science Core Collection, including 765 articles and 576 reviews. Bibliometrix, CiteSpace and VOSviewer software were utilized to examine publications and citations per year, prolific countries, contributive institutions, high-level journals and scholars, as well as highly cited articles, references and keywords. The research of immunotherapy resistance in breast cancer has witnessed a remarkable surge over the past seven years. The United States and China have made significant contributions, with Harvard Medical School being the most prolific institution and actively engaging in collaborations. The most contributive author is Curigliano, G from the European Institute of Oncology in Italy, while Wucherpfennig, K. W. from the Dana-Farber Cancer Institute in the USA, had the highest citations. Journals highly productive primarily focus on clinical, immunology and oncology research. Common keywords include "resistance", "expression", "tumor microenvironment", "cancer", "T cell", "therapy", "chemotherapy" and "cell". Current research endeavors to unravel the mechanisms of immune resistance in breast cancer through the integration of bioinformatics, basic experiments, and clinical trials. Efforts are underway to develop strategies that improve the effectiveness of immunotherapy, including the exploration of combination therapies and advancements in drug delivery systems. Additionally, there is a strong focus on identifying novel biomarkers that can predict patient response to immunology. This study will provide researchers with an up-to-date overview of the present knowledge in drug resistance of immunology for breast cancer, serving as a valuable resource for informed decision-making and further research on innovative approaches to address immunotherapy resistance.
尽管当今乳腺癌的治疗方法已经取得了显著进展,但转移性乳腺癌,尤其是三阴性乳腺癌(TNBC),仍然具有挑战性,生存率较低。癌症免疫疗法是治疗 HER2 阳性和 TNBC 的一种很有前途的方法,但仍然面临着耐药性的障碍。最近,许多研究都着眼于乳腺癌免疫疗法耐药性的研究。通过细致的文献计量分析,我们的研究全面了解了这一关键领域的当前研究现状、热点和新突破。截至 2024 年 3 月 26 日,从 Web of Science 核心合集共收集了 1341 篇关于乳腺癌免疫耐药性的文章,其中 765 篇为文章,576 篇为综述。利用 Bibliometrix、CiteSpace 和 VOSviewer 软件分析了每年发表的出版物和引文数量、主要国家、主要机构、高影响力期刊和学者以及高被引文章、参考文献和关键词。过去七年,乳腺癌免疫疗法耐药性的研究呈显著增长趋势。美国和中国做出了重大贡献,其中哈佛医学院是最具影响力的机构,并积极开展合作。最有贡献的作者是意大利欧洲肿瘤研究所的 Curigliano,G,而美国达纳-法伯癌症研究所的 Wucherpfennig,K.W. 拥有最高的引文。发表论文较多的期刊主要集中在临床、免疫学和肿瘤学研究领域。常见的关键词包括“耐药性”、“表达”、“肿瘤微环境”、“癌症”、“T 细胞”、“治疗”、“化疗”和“细胞”。目前的研究努力通过整合生物信息学、基础实验和临床试验来揭示乳腺癌免疫耐药的机制。正在努力制定提高免疫疗法有效性的策略,包括探索联合疗法和药物输送系统的改进。此外,人们还非常关注确定可以预测患者对免疫疗法反应的新生物标志物。这项研究将为研究人员提供有关乳腺癌免疫耐药性的最新知识概述,为制定明智的决策和进一步研究解决免疫疗法耐药性的创新方法提供有价值的资源。
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