Missed opportunities to increase efficiency of monoclonal antibody development using hybridoma technology and mice as the source animal.
作者信息
Chakravarty Esha, Dorak Mehmet T
机构信息
School of Life Sciences, Pharmacy & Chemistry, Kingston University London, London, United Kingdom.
出版信息
Front Immunol. 2024 Aug 12;15:1443726. doi: 10.3389/fimmu.2024.1443726. eCollection 2024.
Abstract
摘要
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Missed opportunities to increase efficiency of monoclonal antibody development using hybridoma technology and mice as the source animal.利用杂交瘤技术并以小鼠作为源动物来提高单克隆抗体制备效率的错失机会。
Front Immunol. 2024 Aug 12;15:1443726. doi: 10.3389/fimmu.2024.1443726. eCollection 2024.
2
Hybridomas producing hemolytic plaques used to study the relationship between monoclonal antibody affinity and the efficiency of plaque inhibition with increasing concentrations of antigen.用于研究单克隆抗体亲和力与随着抗原浓度增加斑块抑制效率之间关系的产生溶血斑块的杂交瘤。
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Production of Antibodies to Peptide Targets Using Hybridoma Technology.使用杂交瘤技术生产针对肽靶标的抗体。
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The major histocompatibility complex-restricted antigen receptor on T cells. IV. An antiidiotypic antibody predicts both antigen and I-specificity.T细胞上主要组织相容性复合体限制的抗原受体。IV. 一种抗独特型抗体可预测抗原及I特异性。
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Monoclonal antibodies to mouse major histocompatibility complex antigens.针对小鼠主要组织相容性复合体抗原的单克隆抗体。
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The mouse T cell receptor: comparison of MHC-restricted receptors on two T cell hybridomas.小鼠T细胞受体：两种T细胞杂交瘤上MHC限制性受体的比较。
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Updates on the Production of Therapeutic Antibodies Using Human Hybridoma Technique.利用人杂交瘤技术生产治疗性抗体的研究进展
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The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody.T细胞上主要组织相容性复合体限制的抗原受体。I. 用单克隆抗体进行分离。
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[Autoantibody-promoting factor producing hybridoma and suppressive monoclonal anti-Ia antibody (HAK-75)].
Nihon Rinsho. 1985 Jan;43(1):177-80.
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Highly efficient hybridoma generation and screening strategy for anti-PD-1 monoclonal antibody development.高效杂交瘤生成和筛选策略用于抗 PD-1 单克隆抗体开发。
Sci Rep. 2022 Oct 22;12(1):17792. doi: 10.1038/s41598-022-20560-6.
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Hybridoma technology: is it still useful?杂交瘤技术：它仍然有用吗？
Curr Res Immunol. 2021 Mar 22;2:32-40. doi: 10.1016/j.crimmu.2021.03.002. eCollection 2021.
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Development of broadly neutralizing antibodies targeting the cytomegalovirus subdominant antigen gH.开发针对巨细胞病毒亚显性抗原 gH 的广谱中和抗体。
Commun Biol. 2022 Apr 25;5(1):387. doi: 10.1038/s42003-022-03294-z.
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A guide to antigen processing and presentation.抗原加工和呈递指南。
Nat Rev Immunol. 2022 Dec;22(12):751-764. doi: 10.1038/s41577-022-00707-2. Epub 2022 Apr 13.
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Monoclonal Antibodies Generation: Updates and Protocols on Hybridoma Technology.单克隆抗体的产生：杂交瘤技术的更新与方案
Methods Mol Biol. 2022;2435:73-93. doi: 10.1007/978-1-0716-2014-4_6.
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Hybridoma technology a versatile method for isolation of monoclonal antibodies, its applicability across species, limitations, advancement and future perspectives.杂交瘤技术是一种分离单克隆抗体的通用方法，其在不同物种中的适用性、局限性、进展和未来展望。
Int Immunopharmacol. 2020 Aug;85:106639. doi: 10.1016/j.intimp.2020.106639. Epub 2020 May 27.
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