Tian Lei, Jackson Kyle, Chan Michael, Saif Ahmed, He Leon, Didar Tohid F, Hosseinidoust Zeinab
Department of Chemical Engineering McMaster University Hamilton Ontario Canada.
School of Biomedical Engineering McMaster University Hamilton Ontario Canada.
Smart Med. 2022 Dec 23;1(1):e20220015. doi: 10.1002/SMMD.20220015. eCollection 2022 Dec.
The World Health Organization has designated as a global health concern. This designation stems from the emergence of multiple drug-resistant strains that already account for hundreds of thousands of deaths globally. The development of novel treatment strategies to eradicate or mitigate its pathogenic potential is desperately needed. In the effort to develop emerging strategies to combat , phage display is uniquely positioned to assist in this endeavor. Leveraging bacteriophages, phage display enables researchers to better understand interactions between proteins and their antagonists. In doing so, researchers have the capacity to design novel inhibitors, biosensors, disinfectants, and immune modulators that can target specific strains. In this review, we highlight how phage display can be leveraged to design novel solutions to combat . We further discuss existing uses of phage display as a detection, intervention, and prevention platform against and provide outlooks on how this technology can be optimized for future applications.
世界卫生组织已将其指定为全球卫生问题。这一指定源于多种耐药菌株的出现,这些菌株已在全球导致数十万人死亡。迫切需要开发新的治疗策略来根除或减轻其致病潜力。在努力开发对抗它的新兴策略时,噬菌体展示在协助这一努力方面具有独特的地位。利用噬菌体,噬菌体展示使研究人员能够更好地理解蛋白质与其拮抗剂之间的相互作用。通过这样做,研究人员有能力设计出可以靶向特定菌株的新型抑制剂、生物传感器、消毒剂和免疫调节剂。在这篇综述中,我们强调了如何利用噬菌体展示来设计对抗它的新解决方案。我们进一步讨论了噬菌体展示作为针对它的检测、干预和预防平台的现有用途,并展望了如何优化这项技术以用于未来的应用。