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脐血和胎盘拭子微生物培养在快速诊断早产新生儿感染中的相关性:病例报告

Relevance of microbiological cultures of cord blood and placental swabs in the rapid diagnosis of preterm newborn infection due to : A case report.

作者信息

D'Aleo Francesco, Tuscano Attilio, Servello Tarcisio, Tripodi Marcello, Abramo Carmela, Bonanno Roberta, Gulino Ferdinando Antonio, Occhipinti Sara, Incognito Giosuè Giordano, Principe Luigi

机构信息

U.O.C. of Microbiology and Virology, "Bianchi-Melacrino-Morelli" Hospital, Reggio Calabria, Italy.

U.O.C. of Obstetrics and Gynaecology, "Bianchi-Melacrino-Morelli" Hospital, Reggio Calabria, Italy.

出版信息

Case Rep Womens Health. 2024 Jul 25;43:e00638. doi: 10.1016/j.crwh.2024.e00638. eCollection 2024 Oct.

Abstract

() is a Gram-positive bacterium causing listeriosis, a rare but severe foodborne infection, particularly impactful during pregnancy. Maternal-fetal transmission can lead to adverse fetal outcomes, yet symptoms in mothers may be nonspecific, delaying intervention. Despite the severity, the mechanisms of vertical transmission remain unclear. This report describes a case of rapid diagnosis in a preterm newborn using cord blood and placental swabs. A 31-week pregnant woman presented with abdominal pain, diarrhea, and reduced fetal movements after consuming raw sushi. Laboratory findings indicated infection, and she vaginally delivered a live infant with placental and fetal abscesses. Cultures confirmed , with swift diagnosis aided by molecular syndromic testing. The neonate received appropriate antibiotics and was asymptomatic by the end of treatment. This case underscores the need for the rapid diagnosis of maternal-fetal listeriosis, as it poses significant risks during pregnancy, including preterm birth and neonatal complications. Current diagnostic methods often delay treatment. This report emphasizes the use of innovative molecular techniques for early diagnosis, which is crucial in managing neonatal infections, especially in preterm newborns.

摘要

()是一种革兰氏阳性细菌,可引起李斯特菌病,这是一种罕见但严重的食源性感染,在怀孕期间尤其具有影响力。母婴传播可导致不良胎儿结局,然而母亲的症状可能不具特异性,从而延误干预。尽管病情严重,但垂直传播的机制仍不清楚。本报告描述了一例使用脐带血和胎盘拭子对一名早产新生儿进行快速诊断的病例。一名31周孕妇在食用生寿司后出现腹痛、腹泻和胎动减少。实验室检查结果表明存在感染,她经阴道分娩出一名活婴,伴有胎盘和胎儿脓肿。培养结果证实了(),分子综合征检测有助于快速诊断。新生儿接受了适当的抗生素治疗,治疗结束时无症状。该病例强调了快速诊断母婴李斯特菌病的必要性,因为它在怀孕期间会带来重大风险,包括早产和新生儿并发症。目前的诊断方法常常延误治疗。本报告强调使用创新的分子技术进行早期诊断,这对于管理新生儿感染至关重要,尤其是对于早产新生儿。

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