Vázquez-Boland José A, Krypotou Emilia, Scortti Mariela
Division of Infection and Immunity, The Roslin Institute and Edinburgh Medical School (Biomedical Sciences), University of Edinburgh, Edinburgh, United Kingdom
Division of Infection and Immunity, The Roslin Institute and Edinburgh Medical School (Biomedical Sciences), University of Edinburgh, Edinburgh, United Kingdom.
mBio. 2017 Jun 27;8(3):e00949-17. doi: 10.1128/mBio.00949-17.
The Gram-positive facultative intracellular bacterium is the causative agent of listeriosis, a severe food-borne infection. Pregnant women are at risk of contracting listeriosis, which can potentially lead to miscarriage, stillbirth, preterm birth, and congenital neonatal infections. While other systemic bacterial infections may result in adverse pregnancy outcomes at comparable frequencies, has particular notoriety because fetal complications largely occur in the absence of overt illness in the mother, delaying medical intervention. Here, we briefly review the pathophysiology and mechanisms of maternofetal listeriosis, discussed in light of a recent report on transplacental infection in a nonhuman primate model.
革兰氏阳性兼性细胞内细菌是李斯特菌病的病原体，李斯特菌病是一种严重的食源性感染。孕妇有感染李斯特菌病的风险，这可能会导致流产、死产、早产和先天性新生儿感染。虽然其他全身性细菌感染可能以相当的频率导致不良妊娠结局，但李斯特菌病特别臭名昭著，因为胎儿并发症大多在母亲没有明显疾病的情况下发生，从而延误了医疗干预。在此，我们简要回顾母婴李斯特菌病的病理生理学和机制，并根据最近关于非人类灵长类动物模型中经胎盘感染的报告进行讨论。
