Han Dongmei, Yao Yaqi, Wang Fengshuang, He Wenjing, Sun Tianbao, Li Han
The Rehabilitation Department of Nephrology, The First Rehabilitation Hospital of Shanghai, School of Medicine, Tongji University, Shanghai, China.
Yulong County Naxi Autonomous County People's Hospital, Lijiang, Yunnan, China.
Front Med (Lausanne). 2024 Aug 12;11:1416021. doi: 10.3389/fmed.2024.1416021. eCollection 2024.
The study aimed to explore the risk factors for hyperuricemia (HUA) in the Naxi ethnic population residing in high-altitude areas of Yunnan, China, and assess the clinical value of the triglyceride/high-density lipoprotein cholesterol (TG/HDL-c) ratio as a diagnostic marker.
In this cross-sectional study, clinical data were collected from the health checkup population in the People's Hospital of Yulong Naxi Autonomous County, Yunnan Province, from January 2021 to January 2023. Participants were divided into quartiles based on the TG/HDL-c ratio (Q1, Q2, Q3, and Q4) for group analysis using chi-square tests, -tests, and rank sum tests. Logistic regression analysis and linear regression models were employed to further investigate the correlation between the prevalence of hyperuricemia and TG/HDL-c ratio in this high-altitude Naxi population.
A total of 714 participants from the health checkup population were included in the study, of whom 61.5% were male participants and 38.5% were female participants, and the average age was 41.21 ± 11.69 years. The mean uric acid level was 388.51 ± 99.24. After correcting for confounding factors, TG/HDL-c, serum creatinine (Scr), blood urea nitrogen (BUN), triglyceride (TG), high-density lipoprotein cholesterol (HDL-c), red blood cells (RBCs), and hemoglobin (Hb) showed a positive correlation with blood uric acid. Further analysis involved categorizing the TG/HDL-c ratio from a continuous variable to a categorical variable using quartiles. The fully adjusted model showed results that were consistent with the trend observed in the continuous variable analysis when considering the TG/HDL-c ratio as a categorical variable. In addition, in all unadjusted and adjusted models, the serum uric acid (SUA) levels in the high TG/HDL-c ratio group were significantly higher than those in the low TG/HDL-c ratio group (trend < 0.001). Further linear relationship analysis indicated that after adjusting for covariates, there was an approximate linear relationship between the TG/HDL-c and SUA levels, with a coefficient (β) of 5.421.
The prevalence of hyperuricemia is greater in high-altitude areas of Yunnan, showing a nearly linear positive correlation with the TG/HDL-c ratio. Monitoring TG/HDL-c levels may benefit patients with hyperuricemia.
本研究旨在探讨中国云南高海拔地区纳西族人群高尿酸血症（HUA）的危险因素，并评估甘油三酯/高密度脂蛋白胆固醇（TG/HDL-c）比值作为诊断标志物的临床价值。
在这项横断面研究中，收集了云南省玉龙纳西族自治县人民医院2021年1月至2023年1月健康体检人群的临床资料。根据TG/HDL-c比值将参与者分为四分位数（Q1、Q2、Q3和Q4），使用卡方检验、t检验和秩和检验进行组间分析。采用逻辑回归分析和线性回归模型进一步研究该高海拔纳西族人群中高尿酸血症患病率与TG/HDL-c比值之间的相关性。
本研究共纳入714名健康体检人群，其中男性参与者占61.5%，女性参与者占38.5%，平均年龄为41.21±11.69岁。平均尿酸水平为388.51±99.24。校正混杂因素后，TG/HDL-c、血清肌酐（Scr）、血尿素氮（BUN）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-c）、红细胞（RBC）和血红蛋白（Hb）与血尿酸呈正相关。进一步分析是将TG/HDL-c比值从连续变量分类为四分位数的分类变量。当将TG/HDL-c比值视为分类变量时，完全调整模型的结果与连续变量分析中观察到的趋势一致。此外，在所有未调整和调整模型中，高TG/HDL-c比值组的血清尿酸（SUA）水平显著高于低TG/HDL-c比值组（趋势P<0.001）。进一步的线性关系分析表明，校正协变量后，TG/HDL-c与SUA水平之间存在近似线性关系，系数（β）为5.421。
云南高海拔地区高尿酸血症患病率较高，与TG/HDL-c比值呈近似线性正相关。监测TG/HDL-c水平可能对高尿酸血症患者有益。
