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通过光学超分子传感实现尿酸的无创个体化监测，预防高尿酸血症。

Noninvasive and Individual-Centered Monitoring of Uric Acid for Precaution of Hyperuricemia via Optical Supramolecular Sensing.

机构信息

State Key Laboratory of Component-based Chinese Medicine, Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, 300193, China.

出版信息

Adv Sci (Weinh). 2022 Jun;9(18):e2104463. doi: 10.1002/advs.202104463. Epub 2022 Apr 28.

DOI:10.1002/advs.202104463
PMID:35484718
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9218761/
Abstract

Characterized by an excessively increased uric acid (UA) level in serum, hyperuricemia induces gout and also poses a great threat to renal and cardiovascular systems. It is urgent and meaningful to perform early warning by noninvasive diagnosis, thus conducing to blockage of disease aggravation. Here, guanidinocalix[5]arene (GC5A) is successfully identified from the self-built macrocyclic library to specifically monitor UA from urine by the indicator displacement assay. UA is strongly bound to GC5A at micromolar-level, while simultaneously excluding fluorescein (Fl) from the GC5A·Fl complex in the "switch-on" mode. This method successfully differentiates patients with hyperuricemia from volunteers except for those with kidney dysfunction and targets a volunteer at high risk of hyperuricemia. In order to meet the trend from hospital-centered to individual-centered testing, visual detection of UA is studied through a smartphone equipped with a color-scanning feature, whose adaptability and feasibility are demonstrated in sensing UA from authentic urine, leading to a promising method in family-centered healthcare style. A high-throughput and visual detection method is provided here for alarming hyperuricemic by noninvasive diagnosis.

摘要

高尿酸血症的特征是血清中尿酸（UA）水平过高，它会诱发痛风，还会对肾脏和心血管系统造成严重威胁。通过非侵入性诊断进行早期预警是紧迫且有意义的，从而可以阻止疾病恶化。在这里，从自建的大环库中成功鉴定出胍基杯[5]芳烃（GC5A），通过指示剂置换分析特异性地从尿液中监测 UA。UA 在微摩尔水平上与 GC5A 强烈结合，同时以“开启”模式将荧光素（Fl）从 GC5A·Fl 复合物中排除。该方法成功地区分了高尿酸血症患者和志愿者，除了肾功能障碍的志愿者和高尿酸血症高危志愿者。为了满足从医院为中心到以个体为中心的检测趋势，通过配备颜色扫描功能的智能手机对 UA 的可视化检测进行了研究，该方法在真实尿液中检测 UA 的适应性和可行性得到了验证，为以家庭为中心的医疗保健模式提供了一种有前景的方法。这里提供了一种高通量和可视化的检测方法，通过非侵入性诊断对高尿酸血症发出警报。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b90/9218761/352509e16c65/ADVS-9-2104463-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b90/9218761/1b23a43b7507/ADVS-9-2104463-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b90/9218761/775d2c32984a/ADVS-9-2104463-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b90/9218761/59ad1347e395/ADVS-9-2104463-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b90/9218761/6dc675cc9b12/ADVS-9-2104463-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b90/9218761/d4a767a6a173/ADVS-9-2104463-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b90/9218761/352509e16c65/ADVS-9-2104463-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b90/9218761/1b23a43b7507/ADVS-9-2104463-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b90/9218761/775d2c32984a/ADVS-9-2104463-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b90/9218761/59ad1347e395/ADVS-9-2104463-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b90/9218761/6dc675cc9b12/ADVS-9-2104463-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b90/9218761/d4a767a6a173/ADVS-9-2104463-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b90/9218761/352509e16c65/ADVS-9-2104463-g001.jpg

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