Department of Endocrinology, Fuzhou First General Hospital Affiliated with Fujian Medical University, Fuzhou, Fujian, 350009, China.
Department of General Surgery, Fuzhou First General Hospital Affiliated with Fujian Medical University, Fuzhou, Fujian, 350009, China.
Nutr J. 2024 May 4;23(1):48. doi: 10.1186/s12937-024-00953-1.
Limited data regarding the correlation between oxidative balance score (OBS) and hyperuricemia highlights the necessity for thorough investigations. This study aims to examine the link between OBS, which incorporates dietary and lifestyle factors, and the occurrence of hyperuricemia.
We conducted a cross-sectional study involving 13,636 participants from the 2007-2018 National Health and Nutrition Examination Survey (NHANES). The oxidative balance score (OBS) was determined based on four lifestyle factors and sixteen dietary nutrients. We assessed the levels of serum uric acid (SUA) and the occurrence of hyperuricemia as outcomes. Weighted logistic regression and linear models were used for statistical analysis, using Restricted Cubic Splines (RCS) to examine potential nonlinear associations. Subgroup analysis and sensitivity assessments were performed to identify any variations and ensure the robustness of the findings.
Higher OBS was consistently correlated with decreased SUA levels and a reduced prevalence of hyperuricemia. RCS highlighted a significant negative nonlinear association, particularly in females. Subgroup analysis revealed gender-based differences and interactive correlation, providing additional insights regarding OBS and hyperuricemia relationship.
This study underscores a robust negative correlation between OBS and SUA levels as well as the incidence of hyperuricemia, emphasizing the importance of dietary and lifestyle factors. Incorporating RCS, subgroup analysis, and sensitivity assessments enhances the depth of our findings, providing valuable insights for further research.
关于氧化平衡评分（OBS）与高尿酸血症之间相关性的数据有限，这突显了深入研究的必要性。本研究旨在探究包含饮食和生活方式因素的 OBS 与高尿酸血症发生之间的联系。
我们进行了一项横断面研究，共纳入了来自 2007-2018 年全国健康和营养调查（NHANES）的 13636 名参与者。根据四个生活方式因素和十六种饮食营养素来确定氧化平衡评分（OBS）。我们将血清尿酸（SUA）水平和高尿酸血症的发生作为结果进行评估。采用加权逻辑回归和线性模型进行统计学分析，使用限制性三次样条（RCS）来检验潜在的非线性关联。进行亚组分析和敏感性评估，以确定任何变异并确保研究结果的稳健性。
较高的 OBS 与较低的 SUA 水平和较低的高尿酸血症患病率呈持续相关。RCS 突出了显著的负非线性关联，尤其是在女性中。亚组分析揭示了性别差异和交互相关性，为 OBS 与高尿酸血症关系提供了更多的见解。
本研究强调了 OBS 与 SUA 水平以及高尿酸血症发生率之间存在稳健的负相关，突出了饮食和生活方式因素的重要性。通过使用 RCS、亚组分析和敏感性评估，我们的研究结果得到了深化，为进一步的研究提供了有价值的见解。
