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回顾性病例研究：生酮代谢疗法在双相情感障碍难治性抑郁症状有效管理中的应用

Retrospective case study: ketogenic metabolic therapy in the effective management of treatment-resistant depressive symptoms in bipolar disorder.

作者信息

Laurent Nicole

机构信息

Family Renewal, Inc. DBA Mental Health Keto, Vancouver, WA, United States.

出版信息

Front Nutr. 2024 Aug 12;11:1394679. doi: 10.3389/fnut.2024.1394679. eCollection 2024.

DOI:10.3389/fnut.2024.1394679
PMID:39188977
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11346312/
Abstract

This retrospective case study assessed Ketogenic Metabolic Therapy's (KMT) efficacy in a bipolar disorder patient with treatment-resistant depressive symptoms insufficiently controlled by weekly ketamine treatments. Monitoring included relevant biomarkers of ketone production and macronutrient levels, alongside mood evaluations through the Generalized Anxiety Disorder-7 (GAD-7), Depression Anxiety Stress Scales (DASS), and PTSD Checklist for DSM-5 (PCL-5), showing mood stabilization and improved functionality. Qualitative analysis revealed sub-stantial enhancements in functioning, life quality, and mental well-being. This study enriches the metabolic psychiatry literature, emphasizing KMT's potential benefits by integrating quantitative data from recognized psychiatric assessment tools and qualitative insights.

摘要

本回顾性病例研究评估了生酮代谢疗法（KMT）对一名双相情感障碍患者的疗效，该患者存在难治性抑郁症状，每周一次的氯胺酮治疗未能充分控制这些症状。监测内容包括酮生成的相关生物标志物和常量营养素水平，同时通过广泛性焦虑障碍量表-7（GAD-7）、抑郁焦虑压力量表（DASS）和DSM-5创伤后应激障碍检查表（PCL-5）进行情绪评估，结果显示情绪稳定且功能有所改善。定性分析表明，在功能、生活质量和心理健康方面有显著提升。本研究丰富了代谢精神病学文献，通过整合来自公认的精神病学评估工具的定量数据和定性见解，强调了KMT的潜在益处。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f84f/11346312/b1eb6ef1a71e/fnut-11-1394679-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f84f/11346312/28bd36154cca/fnut-11-1394679-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f84f/11346312/fd711fa473fa/fnut-11-1394679-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f84f/11346312/0b40f7880c67/fnut-11-1394679-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f84f/11346312/b1eb6ef1a71e/fnut-11-1394679-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f84f/11346312/28bd36154cca/fnut-11-1394679-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f84f/11346312/fd711fa473fa/fnut-11-1394679-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f84f/11346312/0b40f7880c67/fnut-11-1394679-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f84f/11346312/b1eb6ef1a71e/fnut-11-1394679-g004.jpg

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Psychiatry Res. 2024 May;335:115866. doi: 10.1016/j.psychres.2024.115866. Epub 2024 Mar 20.
2
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Front Psychiatry. 2024 Feb 14;15:1358578. doi: 10.3389/fpsyt.2024.1358578. eCollection 2024.
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The metabolic overdrive hypothesis: hyperglycolysis and glutaminolysis in bipolar mania.
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