Bose Debalina, Famurewa Ademola C, Akash Aman, Othman Eman M
P.K. Sinha Centre for Bioenergy and Renewables, Advanced Technology Development Centre, Indian Institute of Technology, Kharagpur 721302, West Bengal, India.
Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Alex Ekwueme Federal University, Ndufu-Alike Ikwo, P.M.B. 1010, Abakaliki 482131, Nigeria.
J Xenobiot. 2024 Aug 20;14(3):1109-1129. doi: 10.3390/jox14030063.
Within the domain of conventional oncochemotherapeutics, anticancer chemotherapy (AC) has emerged as a potent strategy for the treatment of cancers. AC is the mainstay strategy for solid and non-solid cancer treatment. Its mechanistic action targets the blockage of DNA transcription and the dysregulation of cell cycle machinery in cancer cells, leading to the activation of death pathways. However, the attendant side effect of toxicity inflicted by AC on healthy tissues presents a formidable challenge. The crucial culprit in the AC side effect of toxicity is unknown, although oxidative stress, mitochondrial impairment, inflammatory cascades, autophagy dysregulation, apoptosis, and certain aberrant signaling have been implicated. Honey is a natural bee product with significant health benefits and pharmacological properties. Interestingly, the literature reports that honey may proffer a protection mechanism for delicate tissue/organs against the side effect of toxicity from AC. Thus, this review delves into the prospective role of honey as an alleviator of the AC side effect of toxicity; it provides an elucidation of the mechanisms of AC toxicity and honey's molecular mechanisms of mitigation. The review endeavors to unravel the specific molecular cascades by which honey orchestrates its mitigating effects, with the overarching objective of refining its application as an adjuvant natural product. Honey supplementation prevents AC toxicity via the inhibition of oxidative stress, NF-κB-mediated inflammation, and caspase-dependent apoptosis cascades. Although there is a need for increased mechanistic studies, honey is a natural product that could mitigate the various toxicities induced by AC.
在传统肿瘤化疗领域，抗癌化疗（AC）已成为治疗癌症的有效策略。AC是实体癌和非实体癌治疗的主要策略。其作用机制旨在阻断癌细胞中的DNA转录以及细胞周期机制的失调，从而激活死亡途径。然而，AC对健康组织造成的毒性副作用是一个巨大的挑战。尽管氧化应激、线粒体损伤、炎症级联反应、自噬失调、凋亡以及某些异常信号传导都与之有关，但AC毒性副作用的关键罪魁祸首仍不明确。蜂蜜是一种具有显著健康益处和药理特性的天然蜂产品。有趣的是，文献报道蜂蜜可能为脆弱组织/器官提供一种保护机制，使其免受AC毒性副作用的影响。因此，本综述深入探讨了蜂蜜作为AC毒性副作用缓解剂的潜在作用；阐明了AC毒性的机制以及蜂蜜的缓解分子机制。该综述致力于揭示蜂蜜发挥缓解作用的具体分子级联反应，其总体目标是优化其作为辅助天然产物的应用。补充蜂蜜可通过抑制氧化应激、NF-κB介导的炎症和半胱天冬酶依赖性凋亡级联反应来预防AC毒性。尽管需要增加机制研究，但蜂蜜是一种可以减轻AC诱导的各种毒性的天然产物。
