Martinotti Simona, Pellavio Giorgia, Patrone Mauro, Laforenza Umberto, Ranzato Elia
DiSIT- Dipartimento di Scienze e Innovazione Tecnologica, University of Piemonte Orientale, viale Teresa Michel 11, 15121 Alessandria, Italy.
DiSIT- Dipartimento di Scienze e Innovazione Tecnologica, University of Piemonte Orientale, piazza Sant'Eusebio 5, 13100 Vercelli, Italy.
Life (Basel). 2020 Oct 27;10(11):256. doi: 10.3390/life10110256.
Honey is a natural product with a long use in traditional medicine and is well recognized to regulate different biological events. It is an important source of various biological or pharmacological molecules and, therefore, there is a strong interest to explore their properties. Evidence is growing that honey may have the potential to be an anticancer agent acting through several mechanisms. Here we observed for the first time in a cancer cell line a possible mechanism through which honey could induce an alteration in the intracellular reactive oxygen species and homeostatic balance of intracellular calcium concentration leading to cell death by apoptosis. This mechanism seems to be enhanced by manuka honey's ability to maintain high HO permeability through aquaporin-3.
蜂蜜是一种在传统医学中使用已久的天然产物，其调节不同生物过程的作用已得到广泛认可。它是多种生物或药理分子的重要来源，因此，人们对探索其特性有着浓厚的兴趣。越来越多的证据表明，蜂蜜可能具有通过多种机制发挥抗癌作用的潜力。在这里，我们首次在癌细胞系中观察到一种可能的机制，即蜂蜜可通过改变细胞内活性氧水平和细胞内钙浓度的稳态平衡，导致细胞凋亡死亡。麦卢卡蜂蜜通过水通道蛋白-3维持高水渗透性的能力似乎增强了这一机制。
