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在感染黏液型和非黏液型铜绿假单胞菌的小鼠中,迟发型超敏反应降低,对单核细胞增生李斯特菌的抵抗力增强。

Decreased delayed-type hypersensitivity and increased protection to Listeria monocytogenes seen in mice infected with mucoid and nonmucoid Pseudomonas aeruginosa.

作者信息

Blackwood L L

出版信息

Infect Immun. 1985 Mar;47(3):840-2. doi: 10.1128/iai.47.3.840-842.1985.

Abstract

Infection of mice with Pseudomonas aeruginosa, washed and unwashed, mucoid and nonmucoid, altered subsequent immunity to Listeria monocytogenes. Mice were protected against lethal doses of L. monocytogenes yet exhibited decreased delayed-type hypersensitivity footpad swelling to sublethal doses. The mucoid coating of mucoid P. aeruginosa, an important pathogen in chronic bronchopulmonary disorders, imparted no additional immunomodulating capabilities to P. aeruginosa.

摘要

用黏液型和非黏液型、洗涤过和未洗涤过的铜绿假单胞菌感染小鼠,会改变其随后对单核细胞增生李斯特菌的免疫力。小鼠对致死剂量的单核细胞增生李斯特菌具有抵抗力,但对亚致死剂量的该菌表现出延迟型超敏反应足垫肿胀减轻。黏液型铜绿假单胞菌的黏液涂层是慢性支气管肺部疾病中的一种重要病原体,它并未赋予铜绿假单胞菌额外的免疫调节能力。

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