碱蓬A-D：从海滨碱蓬地上部分分离得到的四种具有抑制一氧化氮生成活性的新化合物。
Suaedamas A-D: Four New Compounds from the Aerial Parts of Suaeda maritima with Inhibition of NO Production Activity.
作者信息
Trang Bui Thi Nha, Anh Bui Thi Mai, Mai Nguyen Thi, Cuc Nguyen Thi, Huyen Le Thi, Nga Nhu Thi Hang, Kiem Phan Van, Tai Bui Huu
机构信息
Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam.
Hanoi University of Natural Resources and Environment, 41 A Phu Dien, North Tu Liem, Hanoi, 10000, Vietnam.
出版信息
Chem Biodivers. 2024 Dec;21(12):e202401787. doi: 10.1002/cbdv.202401787. Epub 2024 Oct 26.
Four new compounds, suaedamas A-D (1-4), and seven known ones (5-11) were isolated from the aerial parts of Suaeda maritima. Their chemical structures were evaluated by the IR, HR-ESI-MS, 1D-, and 2D-NMR, experimental and calculated ECD spectra. Compounds 1-6 inhibited nitric oxide production in LPS activated RAW 264.7 cells with IC values ranging from 29.3 to 85.5 μM, compared to that of the positive control compound, dexamethasone, which showed IC value of 13.4 μM.
从碱蓬地上部分分离得到4个新化合物，即碱蓬酰胺A-D（1-4），以及7个已知化合物（5-11）。通过红外光谱（IR）、高分辨电喷雾电离质谱（HR-ESI-MS）、一维和二维核磁共振（1D-和2D-NMR）、实验和计算的电子圆二色谱（ECD）光谱对其化学结构进行了鉴定。与阳性对照化合物地塞米松（IC值为13.4 μM）相比，化合物1-6对脂多糖激活的RAW 264.7细胞中一氧化氮的产生具有抑制作用，IC值范围为29.3至85.5 μM。
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