Department of Chemistry, University of Massachusetts Amherst, Amherst, MA 01003, USA.
Molecular and Cellular Biology Graduate Program, University of Massachusetts Amherst, Amherst, MA 01003, USA.
Chem Commun (Camb). 2024 Sep 16;60(75):10265-10279. doi: 10.1039/d4cc03077j.
DNA-based nanostructures and nanodevices have recently been employed for a broad range of applications in modulating the assemblies and interaction patterns of different cell membrane receptors. These versatile nanodevices can be rationally designed with modular structures, easily programmed and tweaked such that they may act as smart chemical biology and cell biology tools to reveal insights into complicated cellular signaling processes. Their outstanding and cellular features have also begun to be further validated for some applications and demonstrated their great biomedical potential. In this review, we will highlight some key current advances in the molecular engineering and biological applications of DNA-based functional nanodevices, with a focus on how these tools have been used to respond and modulate membrane receptor dimerizations and/or oligomerizations, as a way to control cellular signaling processes. Some current challenges and future directions to further develop and apply these DNA nanodevices will also be discussed.
基于 DNA 的纳米结构和纳米器件最近被用于广泛的应用中，以调节不同细胞膜受体的组装和相互作用模式。这些多功能的纳米器件可以通过模块化结构进行合理设计，并且易于编程和调整，从而可以作为智能化学生物学和细胞生物学工具，揭示复杂的细胞信号转导过程的见解。它们卓越的性能和细胞特性也开始在一些应用中得到进一步验证，并展示了它们在生物医学方面的巨大潜力。在这篇综述中，我们将重点介绍基于 DNA 的功能纳米器件的分子工程和生物学应用的一些关键进展，以及这些工具如何被用于响应和调节膜受体二聚体和/或寡聚体，以此来控制细胞信号转导过程。我们还将讨论进一步开发和应用这些 DNA 纳米器件所面临的一些挑战和未来的发展方向。
