Ma Yueyue, Liu Caixia, Yang Dali, Fang Ziqi, Huang Wenhui, Cheng Ruihua, Ye Jinxing
School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.
Org Biomol Chem. 2024 Sep 25;22(37):7537-7548. doi: 10.1039/d4ob01210k.
With the development of organic electrochemical synthesis, a series of notable achievements have been made in electrochemical Ritter amination reactions, which have enriched the methods available for constructing C-N bonds. In this review, electrochemical Ritter amination reactions are introduced based on the classification of reaction substrates, including olefins, aromatics, alkylbenzenes, and the less reported carboxylic acids, ketones, sulfides, and alkanes. The application of electrochemical technology to Ritter reactions has improved the harsh conditions of the traditional reactions, and extended the substrate scope and the structural diversity of the products. The application value of Ritter reactions in organic synthesis has also been further expanded.
随着有机电化学合成的发展，电化学 Ritter 胺化反应取得了一系列显著成就，丰富了构建 C-N 键的可用方法。在本综述中，基于反应底物的分类介绍了电化学 Ritter 胺化反应，包括烯烃、芳烃、烷基苯以及报道较少的羧酸、酮、硫化物和烷烃。电化学技术在 Ritter 反应中的应用改善了传统反应的苛刻条件，扩大了底物范围和产物的结构多样性。Ritter 反应在有机合成中的应用价值也得到了进一步拓展。
