海湾战争时期军用杀虫剂施用人员的毒物接触与健康症状。
Toxicant Exposures and Health Symptoms in Military Pesticide Applicators From the 1991 Gulf War.
机构信息
VA Boston Healthcare System, Boston, Massachusetts (M.K., C.G.Z., L.O.); Department of Neurology, Boston University School of Medicine, Boston, Massachusetts (M.K., R.F.W.); Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts (K.S., D.K., L.O., R.F.W.); Behavioral Neurosciences Program, Boston University School of Medicine, Boston, Massachusetts (C.G.Z., R.F.W.); Parsons Corporation (formerly), Syracuse, New York (W.B.); Reliant Medical Group, Worcester, Massachusetts (C.S.); Ibis Reproductive Health, Cambridge, Massachusetts (T.-A.T.); and Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts (T.H.).
出版信息
J Occup Environ Med. 2024 Nov 1;66(11):e584-e592. doi: 10.1097/JOM.0000000000003215. Epub 2024 Aug 26.
OBJECTIVE
The chronic impact of acetylcholinesterase inhibitors and other toxicants on Gulf War (GW) veterans' health symptoms is unclear.
METHODS
Building on reports of adverse neuropsychological outcomes in GW pesticide applicators exposed to pesticides and pyridostigmine bromide, we now report on health symptoms in this group.
RESULTS
In adjusted analyses, applicators with high exposures/impact to pesticides reported significantly more symptoms (18/34 symptoms) than applicators with lower exposures/impact and were more likely to meet modified Kansas and CDC Gulf War Illness criteria. The high pyridostigmine bromide exposure/impact group was 3 times more likely to report irregular heart rates. With regard to specific pesticide types, fly baits, pest strips, and delousers were the most associated with increased health symptom reporting.
CONCLUSIONS
These results suggest that GW veterans with high acetylcholinesterase inhibitor and organochlorine exposures are most at risk for chronic health symptoms.
目的
乙酰胆碱酯酶抑制剂和其他毒物对海湾战争（GW）退伍军人健康症状的慢性影响尚不清楚。
方法
基于海湾战争农药施药者接触杀虫剂和溴化吡啶斯的明后出现不良神经心理学结果的报告，我们现在报告该人群的健康症状。
结果
在调整分析中，高暴露/影响杀虫剂的施药者报告的症状明显更多（18/34 种症状），比低暴露/影响的施药者更有可能符合改良堪萨斯和疾病预防控制中心海湾战争疾病标准。高溴化吡啶斯的明暴露/影响组报告不规则心率的可能性是对照组的 3 倍。关于特定的农药类型，蝇饵、害虫带和除虱剂与增加健康症状报告的相关性最高。
结论
这些结果表明，乙酰胆碱酯酶抑制剂和有机氯暴露水平较高的海湾战争退伍军人患慢性健康症状的风险最高。
Zotero 插件