胸腺在大鼠中用T淋巴细胞系诱导和传递抗佐剂性关节炎疫苗接种中的作用。
Role of the thymus in induction and transfer of vaccination against adjuvant arthritis with a T lymphocyte line in rats.
作者信息
Holoshitz J, Matitiau A, Cohen I R
出版信息
J Clin Invest. 1985 Feb;75(2):472-7. doi: 10.1172/JCI111722.
Abstract
Adjuvant arthritis is an experimental disease of rats induced by immunization to antigens of Mycobacterium tuberculosis. Our observation that arthritis could be induced in irradiated rats by the A2 line of T lymphocytes in the absence of mycobacterial antigens suggested that adjuvant arthritis is an autoimmune disease. Moreover, the A2 line could be used to vaccinate unirradiated rats against the subsequent induction of adjuvant arthritis by active immunization to Mycobacteria. In the present study we found that thymus cells obtained from A2 vaccinated rats could transfer resistance to adjuvant arthritis to naive rats. This indicates that the mechanism of resistance induced by A2 vaccination is probably immunological and involves thymus-derived lymphocytes.
摘要
佐剂性关节炎是通过对结核分枝杆菌抗原进行免疫接种诱导的大鼠实验性疾病。我们观察到，在没有分枝杆菌抗原的情况下，A2系T淋巴细胞可在受辐照大鼠中诱发关节炎，这表明佐剂性关节炎是一种自身免疫性疾病。此外，A2系可用于对未受辐照的大鼠进行接种，使其免受后续通过对分枝杆菌进行主动免疫接种而诱发的佐剂性关节炎。在本研究中，我们发现从接种A2的大鼠中获得的胸腺细胞可将对佐剂性关节炎的抵抗力转移给未接触过该疾病的大鼠。这表明A2接种诱导的抵抗力机制可能是免疫性的，且涉及胸腺来源的淋巴细胞。
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