孕期混合免疫对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的中和及结合抗体反应

Neutralizing and binding antibody responses to SARS-CoV-2 with hybrid immunity in pregnancy.

作者信息

Li Lin, Matsui Yusuke, Prahl Mary K, Cassidy Arianna G, Golan Yarden, Jigmeddagva Unurzul, Ozarslan Nida, Lin Christine Y, Buarpung Sirirak, Gonzalez Veronica J, Chidboy Megan A, Basilio Emilia, Lynch Kara L, Song Dongli, Jegatheesan Priya, Rai Daljeet S, Govindaswami Balaji, Needens Jordan, Rincon Monica, Myatt Leslie, Taha Taha Y, Montano Mauricio, Ott Melanie, Greene Warner C, Gaw Stephanie L

机构信息

Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.

Department of Obstetrics, Gynecology, and Reproductive Sciences, Center for Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.

出版信息

NPJ Vaccines. 2024 Aug 27;9(1):156. doi: 10.1038/s41541-024-00948-3.

Hybrid immunity against SARS-CoV-2 has not been well studied in pregnancy. We conducted a comprehensive analysis of neutralizing antibodies (nAb) and binding antibodies in pregnant individuals who received mRNA vaccination, natural infection, or both. A third vaccine dose augmented nAb levels compared to the two-dose regimen or natural infection alone; this effect was more pronounced in hybrid immunity. There was reduced anti-Omicron nAb, but the maternal-fetal transfer efficiency remained comparable to that of other variants. Vaccine-induced nAbs were transferred more efficiently than infection-induced nAbs. Anti-spike receptor binding domain (RBD) IgG was associated with nAb against wild-type (Wuhan-Hu-1) following breakthrough infection. Both vaccination and infection-induced anti-RBD IgA, which was more durable than anti-nucleocapsid IgA. IgA response was attenuated in pregnancy compared to non-pregnant controls. These data provide additional evidence of augmentation of humoral immune responses in hybrid immunity in pregnancy.

针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的混合免疫在孕期尚未得到充分研究。我们对接受信使核糖核酸（mRNA）疫苗接种、自然感染或两者皆有的孕妇的中和抗体（nAb）和结合抗体进行了全面分析。与两剂接种方案或仅自然感染相比，第三剂疫苗增强了nAb水平；这种效应在混合免疫中更为明显。抗奥密克戎nAb有所降低，但母胎转移效率与其他变体相当。疫苗诱导的nAb比感染诱导的nAb转移效率更高。突破性感染后，抗刺突受体结合域（RBD）IgG与针对野生型（武汉-1）的nAb相关。接种疫苗和感染均诱导产生抗RBD IgA，其比抗核衣壳IgA更持久。与非孕对照组相比，孕期IgA反应减弱。这些数据为孕期混合免疫中体液免疫反应增强提供了更多证据。