Centre for Cancer Screening, Prevention and Early Diagnosis, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Cancer Prevention Group, School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.
Br J Cancer. 2024 Oct;131(7):1202-1211. doi: 10.1038/s41416-024-02822-4. Epub 2024 Aug 27.
Trials assessing the clinical utility of blood-based multi-cancer early detection (MCED) tests are underway. Understanding public attitudes towards MCED screening is essential if these tests are to be used. We aimed to quantify MCED screening intention and potential barriers and facilitators to uptake.
Adults aged 50-77 (n = 958) completed an online survey. The primary outcome was intention to have MCED screening if offered. Psychological variables including barriers and facilitators were assessed. We used logistic regressions to explore associations between socio-demographics and psychological factors and intention.
93.8% of participants said they would 'definitely' or 'probably' have MCED screening if offered. Intention was significantly associated with previous screening participation and general cancer attitudes but not with socio-demographic factors. Participants were more likely to be intenders if they had higher health motivation, and perceived greater benefits of blood tests. Participants were less likely to be intenders if they perceived greater disadvantages of blood tests, more practical barriers, were more worried about the outcome and more concerned about a positive result.
MCED screening intention was high. The lack of socio-demographic variation suggests equitable interest in this type of screening; however, future research should consider how intention translates to uptake.
评估基于血液的多种癌症早期检测（MCED）试验的临床实用性的试验正在进行中。如果要使用这些测试，了解公众对 MCED 筛查的态度至关重要。我们旨在量化 MCED 筛查的意向，以及接受筛查的潜在障碍和促进因素。
年龄在 50-77 岁之间的成年人（n=958）完成了一项在线调查。主要结果是如果提供 MCED 筛查，是否有接受筛查的意愿。评估了包括障碍和促进因素在内的心理变量。我们使用逻辑回归来探讨社会人口统计学和心理因素与意向之间的关联。
93.8%的参与者表示，如果提供 MCED 筛查，他们“肯定”或“可能”会接受。意向与之前的筛查参与和一般癌症态度显著相关，但与社会人口统计学因素无关。如果参与者有更高的健康动机，并且认为血液检测的益处更大，他们更有可能成为意向者。如果参与者认为血液检测的劣势更大、实际障碍更多、更担心结果、更担心阳性结果，他们就不太可能成为意向者。
MCED 筛查的意愿很高。缺乏社会人口统计学方面的差异表明，人们对这种类型的筛查有平等的兴趣；然而，未来的研究应该考虑意向如何转化为接受度。
