Reiter Paul L, Katz Mira L
College of Public Health, The Ohio State University, Columbus, OH, USA.
Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Cancer Causes Control. 2025 May 31. doi: 10.1007/s10552-025-02014-2.
Multicancer detection (MCD) testing is an emerging approach with the potential to improve the cancer screening and early detection landscape. As the clinical utility of MCD testing is further determined, it is important to examine patients' willingness to have an MCD test.
We conducted an online survey in September 2024 with a national sample of adults aged 45-80 from the United States (n = 1,043). Multivariable logistic regression identified correlates of participants' willingness to have an MCD test.
About three-fourths of participants (75.2%) indicated they were willing to have an MCD test if it was free or covered by health insurance, while only 16.9% were willing if the test cost $1,000 out of pocket. Participants were more willing to have a free MCD test if they had at least a college degree (odds ratio [OR] = 2.48, 95% confidence interval [CI] 1.12-5.48), had some form of health insurance (OR = 3.40, 95% CI 1.84-6.27), or had a routine medical check-up within the last year (OR = 1.62, 95% CI 1.01-2.59). The most commonly endorsed factors that would matter in participants' hypothetical MCD testing decisions were cost or health insurance coverage (60.7%), how well the test works (50.6%), and if a doctor recommended having a test (47.6%).
Most adults are willing to have an MCD test, if it is free or covered by health insurance. Findings can help guide programs about MCD testing for both patients and healthcare providers that are becoming increasingly necessary as MCD testing continues to be examined as a screening strategy.
多癌检测（MCD）测试是一种新兴方法，有潜力改善癌症筛查和早期检测的局面。随着MCD测试的临床效用进一步确定，研究患者进行MCD测试的意愿很重要。
我们于2024年9月对来自美国的45至80岁成年人全国样本（n = 1,043）进行了在线调查。多变量逻辑回归确定了参与者进行MCD测试意愿的相关因素。
约四分之三的参与者（75.2%）表示，如果MCD测试免费或由医疗保险覆盖，他们愿意进行测试，而如果测试自付费用为1000美元，只有16.9%的人愿意。如果参与者至少拥有大学学位（优势比[OR] = 2.48，95%置信区间[CI] 1.12 - 5.48）、拥有某种形式的医疗保险（OR = 3.40，95% CI 1.84 - 6.27）或在过去一年进行过常规体检（OR = 1.62，95% CI 1.01 - 2.59），他们更愿意进行免费的MCD测试。在参与者假设的MCD测试决策中，最常被认可的重要因素是成本或医疗保险覆盖范围（60.7%）、测试的有效性（50.6%）以及医生是否推荐进行测试（47.6%）。
如果MCD测试免费或由医疗保险覆盖，大多数成年人愿意进行该测试。随着MCD测试作为一种筛查策略不断受到审视，这些发现可为针对患者和医疗服务提供者的MCD测试项目提供指导，此类项目正变得越来越必要。
