Nelson M, Nelson D S
J Natl Cancer Inst. 1985 Mar;74(3):637-45.
Stimulation of [methyl-3H]thymidine incorporation in mixed cultures of mouse peritoneal cells (PC) and tumor cells required a large adherent PC. Flow cytometric analysis, as well as autoradiography, showed that the stimulation involved increased proliferation of tumor cells. The stimulation required contact between tumor and PC; it was partly inhibited by Trasylol (aprotinin) and potentiated by dexamethasone. In addition, there was minor stimulation of PC by a soluble product of tumor cells; this stimulation was not affected by Trasylol or dexamethasone. It is suggested that macrophages can stimulate tumor cell proliferation and that such stimulation may be an important factor in host-tumor relationships.
在小鼠腹膜细胞（PC）与肿瘤细胞的混合培养物中，刺激[甲基-³H]胸腺嘧啶核苷掺入需要大量贴壁PC。流式细胞术分析以及放射自显影表明，这种刺激涉及肿瘤细胞增殖增加。该刺激需要肿瘤细胞与PC之间的接触；它部分受到抑肽酶抑制，而地塞米松可增强其作用。此外，肿瘤细胞的可溶性产物对PC有轻微刺激；这种刺激不受抑肽酶或地塞米松的影响。提示巨噬细胞可刺激肿瘤细胞增殖，且这种刺激可能是宿主与肿瘤关系中的一个重要因素。
