School of Computer Science, McGill University, Montréal, QC, H3A 0E9, Canada.
Beam Me Up Inc., 5925 Monkland Ave, Suite, 100, Montréal, H4A 1G7, Canada.
BMC Bioinformatics. 2024 Aug 27;25(1):277. doi: 10.1186/s12859-024-05882-8.
Over the past two decades, scientists have increasingly realized the importance of the three-dimensional (3D) genome organization in regulating cellular activity. Hi-C and related experiments yield 2D contact matrices that can be used to infer 3D models of chromosome structure. Visualizing and analyzing genomes in 3D space remains challenging. Here, we present ARGV, an augmented reality 3D Genome Viewer. ARGV contains more than 350 pre-computed and annotated genome structures inferred from Hi-C and imaging data. It offers interactive and collaborative visualization of genomes in 3D space, using standard mobile phones or tablets. A user study comparing ARGV to existing tools demonstrates its benefits.
在过去的二十年中，科学家们越来越意识到三维（3D）基因组组织在调节细胞活动中的重要性。Hi-C 和相关实验产生了 2D 接触矩阵，可用于推断染色体结构的 3D 模型。在 3D 空间中可视化和分析基因组仍然具有挑战性。在这里，我们展示了 ARGV，一个增强现实的 3D 基因组浏览器。ARGV 包含了超过 350 个从 Hi-C 和成像数据中推断出来的预先计算和注释的基因组结构。它使用标准的移动电话或平板电脑提供了 3D 空间中基因组的交互式和协作可视化。一项将 ARGV 与现有工具进行比较的用户研究证明了它的优势。
