巨大芽孢杆菌感染致肺泡蛋白沉积症 1 例报告
Bacillus megaterium infection presenting as pulmonary alveolar proteinosis, a case report.
机构信息
Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Shuaifuyuan Street, Dongcheng District, Beijing, 100730, China.
Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
出版信息
BMC Infect Dis. 2024 Aug 27;24(1):868. doi: 10.1186/s12879-024-09713-2.
BACKGROUND
Pulmonary alveolar proteinosis (PAP) is a special clinical presentation mostly associated with autoimmune disorders. Here we report a rare case of PAP secondary to infection of Bacillus megaterium.
CASE PRESENTATION
A 58-year-old woman presented with intermittent cough and dyspnea for half a year. Chest CT scan showed "crazy paving" pattern. B. megaterium was identified by percutaneous CT-guided needle biopsy. She continuously received antimicrobial treatment since the diagnosis and follow-up examination suggested great improvement.
CONCLUSIONS
To our knowledge, this is the first case of B. megaterium infection presented with PAP pattern in healthy individuals. Attention should be paid on the secondary causes including rare pathogen infection when patients presented with PAP syndrome.
背景
肺泡蛋白沉积症（PAP）是一种特殊的临床表现，主要与自身免疫性疾病有关。在这里，我们报告了一例由巨大芽孢杆菌感染引起的 PAP 罕见病例。
病例介绍
一名 58 岁女性因间歇性咳嗽和呼吸困难半年就诊。胸部 CT 扫描显示“铺路石”样改变。经皮 CT 引导下针吸活检鉴定出巨大芽孢杆菌。自诊断以来，她一直接受抗菌治疗，随访检查提示病情明显改善。
结论
据我们所知，这是首例健康个体中由巨大芽孢杆菌感染引起的 PAP 模式的病例。当患者出现 PAP 综合征时，应注意包括罕见病原体感染在内的继发性病因。
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