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全球首例用于心脏移植的体外循环杂交系统的应用。

First worldwide use of the hybrid system for extracorporeal circulation in heart transplant.

机构信息

Department of Cardiovascular Surgery, Koşuyolu High Specialization Education and Research Hospital, Koşuyolu YİEA Hastanesi, Denizer Caddesi No:2, Cevizli Kavşağı, Kartal, Istanbul, 34865, Türkiye.

Department of Anesthesia, Koşuyolu High Specialization Education and Research Hospital, Istanbul, Türkiye.

出版信息

J Cardiothorac Surg. 2024 Aug 27;19(1):495. doi: 10.1186/s13019-024-03010-4.

DOI:10.1186/s13019-024-03010-4
PMID:39192346
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11351644/
Abstract

BACKGROUND

This case report documents the first worldwide use of the Hybrid System from Spectrum Medical in a heart transplant procedure, focusing on its safety and efficacy. Traditional cardiopulmonary bypass systems often use an open reservoir, which increases the blood's exposure to air, thereby heightening the risk of an inflammatory response and gas embolism. In contrast, the Hybrid System is designed to improve surgical outcomes by significantly reducing the blood-air interface. This system utilizes a dual-chamber cardiotomy-venous reservoir with a collapsible soft bag, effectively minimizing blood contact with air and foreign materials. However, it is important to note that there is currently no evidence supporting the use of this methodology specifically in heart transplants.

CASE PRESENTATION

A 41-year-old male managed with a left ventricular assist device because of dilated cardiomyopathy underwent a heart transplant using the Hybrid System. The perioperative and postoperative data provided evidence of the system's effectiveness. The selection of this patient was due to the absence of significant comorbidities unrelated to his primary cardiac condition, making him an ideal candidate to evaluate the system's performance.

CONCLUSION

The Hybrid System is safe and efficient. The successful implementation in this case highlights its advantages over traditional cardiopulmonary bypass systems, suggesting a promising future in cardiac surgery. Further studies with routine cardiac surgery patients are required to validate these findings.

摘要

背景

本病例报告记录了 Spectrum Medical 公司的 Hybrid 系统在心脏移植手术中的首次全球应用,重点关注其安全性和有效性。传统的体外循环系统通常使用开放式储液器,这会增加血液与空气的接触,从而增加炎症反应和气体栓塞的风险。相比之下,Hybrid 系统旨在通过显著减少血液-空气界面来改善手术结果。该系统采用带可折叠软袋的双腔心腔-静脉储液器,有效减少血液与空气和异物的接触。然而,需要注意的是,目前尚无证据支持该方法专门用于心脏移植。

病例介绍

一名 41 岁男性因扩张型心肌病使用左心室辅助装置治疗,随后使用 Hybrid 系统进行心脏移植。围手术期和术后数据提供了系统有效性的证据。选择该患者是因为他没有与主要心脏状况无关的重要合并症,使其成为评估系统性能的理想人选。

结论

Hybrid 系统是安全有效的。该系统在该病例中的成功应用突出了其相对于传统体外循环系统的优势,为心脏手术的未来发展带来了希望。需要对常规心脏手术患者进行进一步研究来验证这些发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/654f/11351644/5f4a15841ce7/13019_2024_3010_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/654f/11351644/521ac45885d8/13019_2024_3010_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/654f/11351644/5f4a15841ce7/13019_2024_3010_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/654f/11351644/521ac45885d8/13019_2024_3010_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/654f/11351644/5f4a15841ce7/13019_2024_3010_Fig2_HTML.jpg

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Hypobaric type oxygenators - physics and physiology.低压型氧合器——物理与生理学
Perfusion. 2025 Mar;40(2):273-282. doi: 10.1177/02676591241232824. Epub 2024 Feb 7.
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The effect of vacuum-assisted venous drainage on hemolysis during cardiopulmonary bypass.体外循环期间真空辅助静脉引流对溶血的影响。
Am J Cardiovasc Dis. 2020 Oct 15;10(4):473-478. eCollection 2020.
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Air, inflammation and biocompatibility of the extracorporeal circuits.体外循环的空气、炎症和生物相容性。
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The influence of gaseous microemboli on various biomarkers after minimized cardiopulmonary bypass.气体微栓对微创体外循环后各种生物标志物的影响。
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Is 300 Seconds ACT Safe and Efficient during MiECC Procedures?在微创体外循环(MiECC)手术中,300秒激活凝血时间(ACT)是否安全且高效?
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