Division of Nephrology, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Mol Nutr Food Res. 2024 Sep;68(18):e2400373. doi: 10.1002/mnfr.202400373. Epub 2024 Aug 27.
This study aims to assess the association between intake of different types of fruit (citrus, pomes, tropical fruits, berries, gourds, drupes, dried fruits, and other fruits), the intake diversity of fruit types, and risk of new-onset kidney stones in general population.
A total of 205 896 participants with at least one completed 24-h dietary recall from the UK Biobank are included. During a median follow-up of 11.6 years, 2074 cases of kidney stones are documented. Compared with nonconsumers, participants with higher intake of citrus (50-<100 g day; hazards ratio [HR] = 0.78; 95% confidence interval [CI], 0.66-0.91; ≥100 g day; HR = 0.75; 95%CI, 0.63-0.89), pomes (≥100 g day; HR = 0.86; 95%CI, 0.77-0.96), or tropical fruits (50-<100 g day; HR = 0.86; 95%CI, 0.75-0.99; ≥100 g day; HR = 0.88; 95%CI, 0.79-0.99) have a lower risk of new-onset kidney stones. However, there is no significant association of intake of berries, gourds, drupes, dried fruits, and other fruits with kidney stones. A higher fruit variety score is significantly associated with a lower risk of new-onset kidney stones (per 1-score increment, HR = 0.86; 95%CI, 0.81-0.91).
Higher intake of citruses (≥50 g day), pomes (≥100 g day), and tropical fruits (≥50 g day), as well as increasing diversity of intake of these three fruits, are associated with a lower risk of new-onset kidney stones.
本研究旨在评估不同类型水果（柑橘类、梨果类、热带水果、浆果、瓜类、核果、干果和其他水果）的摄入量、水果类型摄入多样性与普通人群新发肾结石风险之间的关系。
共纳入来自英国生物库的 205896 名至少完成一次 24 小时膳食回忆的参与者。在中位随访 11.6 年期间，共记录到 2074 例肾结石病例。与非食用者相比，柑橘类（50-<100g/天，危险比[HR] = 0.78；95%置信区间[CI]，0.66-0.91；≥100g/天，HR = 0.75；95%CI，0.63-0.89）、梨果类（≥100g/天，HR = 0.86；95%CI，0.77-0.96）或热带水果（50-<100g/天，HR = 0.86；95%CI，0.75-0.99；≥100g/天，HR = 0.88；95%CI，0.79-0.99）摄入量较高的参与者新发肾结石的风险较低。然而，摄入浆果、瓜类、核果、干果和其他水果与肾结石之间无显著相关性。水果种类评分较高与新发肾结石风险降低显著相关（每增加 1 分，HR = 0.86；95%CI，0.81-0.91）。
较高的柑橘类（≥50g/天）、梨果类（≥100g/天）和热带水果（≥50g/天）摄入量，以及增加这三种水果的摄入多样性，与新发肾结石风险降低相关。
