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儿童髋关节疾病与 55 岁以下全髋关节置换术后 10 年翻修风险增加无关:荷兰关节置换登记处的结果。

Pediatric hip disorders are not associated with an increased 10-year revision risk after total hip arthroplasty under the age of 55: results from the Dutch Arthroplasty Register.

机构信息

Department of Orthopedic Surgery, Leiden University Medical Center, Leiden

Department of Orthopedic Surgery, Leiden University Medical Center, Leiden; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden.

出版信息

Acta Orthop. 2024 Aug 28;95:472-476. doi: 10.2340/17453674.2024.41342.

Abstract

BACKGROUND AND PURPOSE

Developmental dysplasia (DDH) and Legg-Calvé-Perthes disease (LCPD) are common indications for total hip arthroplasty (THA) at a young age, and may be associated with increased revision risk. We aimed to investigate the 10-year cumulative aseptic cup revision and overall revision risk of THA, and investigated whether these are increased compared with THA for primary osteoarthritis (OA) in patients below 55 years.

METHODS

All THAs (2007-2019) in patients under the age of 55 for the indications OA, DDH, and LCPD were extracted from the Dutch Arthroplasty register. The 10-year cumulative incidences of aseptic cup failure and overall revision were assessed for the 3 groups, with death as a competing risk. Cox regression analysis was used.

RESULTS

24,263 THAs were identified: 20,645 (85%) for OA, 3,032 (13%) for DDH, and 586 (2%) for LCPD. The 10-year cumulative revision risk for aseptic cup failure was 3.4% (95% confidence interval [CI] 3.0-3.8) for OA, 3.4% (CI 2.4-3.4) for DDH, and 1.7% (CI 0.2-3.1) for LCPD. The 10-year cumulative overall revision risk was 6.0% (CI 5.6-6.5) for OA, 6.0% (CI 4.9-7.2) for DDH, and 5.1% (2.7-7.5) for LCPD. The multivariable Cox regression analysis for aseptic cup failure yielded hazard ratios of 0.7 (0.5-1.2) for DDH, and 0.8 (0.3-2.1) for LCPD compared with OA. No statistically significant differences for overall revision were found.

CONCLUSION

THA performed for DDH or LCDP in patients under the age of 55 was not associated with a statistically significant increased risk of aseptic cup revision or overall revision, compared with THA performed for primary OA in the same age group.

摘要

背景与目的

发育性髋关节发育不良(DDH)和Legg-Calvé-Perthes 病(LCPD)是年轻患者行全髋关节置换术(THA)的常见适应证,可能与翻修风险增加相关。我们旨在研究 10 年累积无菌髋臼翻修和 THA 的总体翻修风险,并探讨与 55 岁以下原发性骨关节炎(OA)患者相比,这些风险是否增加。

方法

从荷兰关节置换登记处提取了年龄在 55 岁以下的患者因 OA、DDH 和 LCPD 接受 THA 的所有数据(2007-2019 年)。评估了 3 组患者的 10 年无菌髋臼失败和总体翻修的累积发生率,以死亡为竞争风险。采用 Cox 回归分析。

结果

共纳入 24263 例 THA:20645 例(85%)为 OA,3032 例(13%)为 DDH,586 例(2%)为 LCPD。无菌髋臼失败的 10 年累积翻修风险为 OA 组 3.4%(95%置信区间 [CI] 3.0-3.8),DDH 组 3.4%(CI 2.4-3.4),LCPD 组 1.7%(CI 0.2-3.1)。10 年总体翻修风险为 OA 组 6.0%(CI 5.6-6.5),DDH 组 6.0%(CI 4.9-7.2),LCPD 组 5.1%(2.7-7.5)。无菌髋臼失败的多变量 Cox 回归分析显示,与 OA 相比,DDH 的危险比为 0.7(0.5-1.2),LCPD 为 0.8(0.3-2.1)。未发现总体翻修有统计学显著差异。

结论

与同年龄组原发性 OA 患者相比,55 岁以下患者行 DDH 或 LCPD 所致 THA 与无菌髋臼翻修或总体翻修的风险无统计学显著增加相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e92d/11350965/d11b0b8a73c7/ActaO-95-41342-g001.jpg

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