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基于人群的髋关节和膝关节骨关节炎置换术后 10 年累积修订风险,以在临床实践中为患者提供信息:荷兰关节置换登记处的竞争风险分析。

Population-based 10-year cumulative revision risks after hip and knee arthroplasty for osteoarthritis to inform patients in clinical practice: a competing risk analysis from the Dutch Arthroplasty Register.

机构信息

Department of Orthopaedics, Leiden University Medical Center, Leiden.

Department of Clinical Epidemiology, Leiden University Medical Center, Leiden.

出版信息

Acta Orthop. 2021 Jun;92(3):280-284. doi: 10.1080/17453674.2021.1876998. Epub 2021 Jan 22.

Abstract

Background and purpose - A lifetime perspective on revision risks is needed for optimal timing of arthroplasty in osteoarthritis (OA) patients, weighing the benefit of total hip arthroplasty/total knee arthroplasty (THA/TKA) against the risk of revision, after which outcomes are less favorable. Therefore, we provide population-based 10-year cumulative revision risks stratified by joint, sex, fixation type, and age.Patients and methods - Data from the Dutch Arthroplasty Register (LROI) was used. Primary THAs and TKAs for OA between 2007 and 2018 were included, except metal-on-metal prostheses or hybrid/reversed hybrid fixation. Revision surgery was defined as any change of 1 or more prosthesis components. The 10-year cumulative revision risks were calculated stratified by joint, age, sex, at primary arthroplasty, and fixation type (cemented/uncemented), taking into account mortality as a competing risk. We estimated the percentage of potentially avoidable revisions assuming all OA patients aged < 75 received primary THA/TKA 5 years later while keeping age-specific 10-year revision risks constant.Results - 214,638 primary THAs and 211,099 TKAs were included, of which 31% of THAs and 95% of TKAs were cemented. The 10-year cumulative revision risk varied between 1.6% and 13%, with higher risks in younger age categories. Delaying prosthesis placement by 5 years could potentially avoid 23 (3%) THA and 162 (17%) TKA revisions.Interpretation - Cumulative 10- year revision risk varied considerably by age in both fixation groups, which may be communicated to patients and used to guide timing of surgery.

摘要

背景与目的-对于骨关节炎(OA)患者,需要从终身角度考虑翻修风险,权衡全髋关节置换术/全膝关节置换术(THA/TKA)的获益与翻修风险,因为翻修后结局不太理想。因此,我们提供了基于人群的 10 年累积翻修风险,按关节、性别、固定类型和年龄分层。

患者和方法-使用荷兰关节置换登记处(LROI)的数据。纳入了 2007 年至 2018 年期间因 OA 行初次 THA 和 TKA 的患者,但不包括金属对金属假体或混合/反向混合固定。翻修手术定义为任何 1 个或多个假体部件的更换。考虑到死亡率是一种竞争风险,按关节、初次置换时的年龄、性别和固定类型(骨水泥固定/非骨水泥固定)分层计算 10 年累积翻修风险。我们假设所有<75 岁的 OA 患者都将初次 THA/TKA 推迟 5 年,同时保持特定年龄组的 10 年翻修风险不变,以此来估计潜在可避免的翻修比例。

结果-共纳入 214638 例初次 THA 和 211099 例初次 TKA,其中 31%的 THA 和 95%的 TKA 为骨水泥固定。10 年累积翻修风险在 1.6%至 13%之间,年轻患者风险更高。将假体放置推迟 5 年可能会避免 23 例(3%)THA 和 162 例(17%)TKA 翻修。

结论-在两组固定患者中,10 年累积翻修风险在不同年龄组之间差异较大,这可能有助于与患者沟通,并用于指导手术时机。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/931e/8237834/dbe5de075e67/IORT_A_1876998_F0001_C.jpg

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