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用于诊断淋巴结癌转移的双色荧光树枝状大分子的合成

Synthesis of a Dual-Color Fluorescent Dendrimer for Diagnosis of Cancer Metastasis in Lymph Nodes.

作者信息

Kojima Chie, Nagai Kento

机构信息

Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, 1-1, Gakuen-cho, Naka-ku, Sakai 599-8531, Osaka, Japan.

出版信息

Polymers (Basel). 2022 Oct 14;14(20):4314. doi: 10.3390/polym14204314.

DOI:10.3390/polym14204314
PMID:36297891
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9607438/
Abstract

Detection of cancer metastasis spread in lymph nodes is important in cancer diagnosis. In this study, a fluorescence imaging probe was designed for the detection of both lymph node and tumor cells using always-ON and activatable fluorescence probes with different colors. Rhodamine B (Rho), a matrix metalloproteinase-2 (MMP-2)-responsive green fluorescence probe, and a tumor-homing peptide were conjugated to a carboxy-terminal dendrimer that readily accumulates in lymph nodes. The activatable green fluorescence signal increased in the presence of MMP-2, which is secreted by tumor cells. Both the always-ON Rho signal and the activatable green fluorescence signal were observed from tumor cells, but only the weak always-ON Rho signal was from immune cells. Thus, this type of dendrimer may be useful for non-invasive imaging to diagnose cancer metastasis in lymph nodes.

摘要

检测癌症在淋巴结中的转移扩散对癌症诊断至关重要。在本研究中，设计了一种荧光成像探针，使用具有不同颜色的恒亮型和可激活荧光探针来检测淋巴结和肿瘤细胞。罗丹明B（Rho），一种基质金属蛋白酶-2（MMP-2）响应性绿色荧光探针，与一种肿瘤归巢肽偶联到一个易于在淋巴结中积聚的羧基末端树枝状聚合物上。在肿瘤细胞分泌的MMP-2存在下，可激活的绿色荧光信号增强。在肿瘤细胞中同时观察到恒亮型Rho信号和可激活的绿色荧光信号，但免疫细胞仅发出微弱的恒亮型Rho信号。因此，这种类型的树枝状聚合物可能有助于用于非侵入性成像以诊断淋巴结中的癌症转移。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1803/9607438/13b0cd8d3123/polymers-14-04314-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1803/9607438/c0db50dad337/polymers-14-04314-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1803/9607438/93fdf3697cf7/polymers-14-04314-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1803/9607438/a03814382d99/polymers-14-04314-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1803/9607438/13b0cd8d3123/polymers-14-04314-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1803/9607438/c0db50dad337/polymers-14-04314-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1803/9607438/93fdf3697cf7/polymers-14-04314-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1803/9607438/a03814382d99/polymers-14-04314-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1803/9607438/13b0cd8d3123/polymers-14-04314-g004.jpg

相似文献

[1]
Synthesis of a Dual-Color Fluorescent Dendrimer for Diagnosis of Cancer Metastasis in Lymph Nodes.

Polymers (Basel). 2022-10-14

[2]
Design of a dendrimer with a matrix metalloproteinase-responsive fluorescence probe and a tumor-homing peptide for metastatic tumor cell imaging in the lymph node.

Bioorg Med Chem Lett. 2021-2-1

[3]
Tumor microenvironment-responsive fluorogenic nanoprobe for ratiometric dual-channel imaging of lymph node metastasis.

Colloids Surf B Biointerfaces. 2019-3-21

[4]
Rational Design and Synthesis of a Metalloproteinase-Activatable Probe for Dual-Modality Imaging of Metastatic Lymph Nodes in Vivo.

J Org Chem. 2019-5-2

[5]
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[6]
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JMIR Res Protoc. 2020-8-14

[7]
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[8]
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[9]
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Anticancer Res. 2013-2

[10]
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Gynecol Oncol. 2017-6-17

引用本文的文献

[1]
Application of hydrogels in cancer immunotherapy: a bibliometric analysis.

Front Immunol. 2024

本文引用的文献

[1]
Specific diagnosis of lymph node micrometastasis in breast cancer by targeting activatable near-infrared fluorescence imaging.

Biomaterials. 2022-3

[2]
Activatable fluorescence sensors for bio-detection in the second near-infrared window.

Chem Sci. 2020-11-12

[3]
Design of a dendrimer with a matrix metalloproteinase-responsive fluorescence probe and a tumor-homing peptide for metastatic tumor cell imaging in the lymph node.

Bioorg Med Chem Lett. 2021-2-1

[4]
Association of Hydrophobic Carboxyl-Terminal Dendrimers with Lymph Node-Resident Lymphocytes.

Polymers (Basel). 2020-6-30

[5]
Carboxyl-, sulfonyl-, and phosphate-terminal dendrimers as a nanoplatform with lymph node targeting.

Int J Pharm. 2020-1-7

[6]
Physical and chemical profiles of nanoparticles for lymphatic targeting.

Adv Drug Deliv Rev. 2019-10-15

[7]
Fluorescence Guided Sentinel Lymph Node Mapping: From Current Molecular Probes to Future Multimodal Nanoprobes.

Bioconjug Chem. 2018-12-17

[8]
Dendrimers: A versatile nanocarrier for drug delivery and targeting.

Int J Pharm. 2018-7-21

[9]
Recent developments in multimodality fluorescence imaging probes.

Acta Pharm Sin B. 2018-5

[10]
Lymph node metastases: importance of detection and treatment strategies.

Expert Opin Drug Deliv. 2018-3-6

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