Lacy Brian E, Wise Journey L, Cangemi David J
Division of Gastroenterology & Hepatology, Mayo Clinic Jacksonville, Jacksonville, Florida.
Graduate Research Education Program, Mayo Clinic Rochester, Rochester, Minnesota.
Gastroenterol Hepatol (N Y). 2024 Aug;20(5):264-272.
Leaky gut syndrome is a condition widely popularized in the lay literature, although it is not currently accepted as a formal medical diagnosis. Multiple gastrointestinal symptoms are ascribed to leaky gut syndrome, including diarrhea, bloating, distension, abdominal pain, and dyspeptic symptoms of early satiety, nausea, and postprandial fullness. The etiology and pathophysiology of leaky gut syndrome are multifactorial; a preceding gastrointestinal infection, inflammatory bowel disease, and certain medications may be relevant factors in some patients. The diagnosis of leaky gut syndrome is problematic. Although patients are frequently informed that the diagnosis can be readily made using results from blood work or stool studies, no validated test currently exists to make this diagnosis. Patients report a variety of myths about the etiology, diagnosis, and treatment of leaky gut syndrome, which can cause alarm and can frequently lead to expensive, unnecessary tests and unproven, sometimes dangerous treatments. This article reviews some of the most common myths about leaky gut syndrome and provides data from the scientific literature to correct these statements. Management strategies, based on data, are provided when available.
肠漏综合征是一种在非专业文献中广泛流传的病症，尽管目前它尚未被认可为一种正式的医学诊断。多种胃肠道症状被归因于肠漏综合征，包括腹泻、腹胀、腹部膨隆、腹痛以及诸如早饱、恶心和餐后饱胀等消化不良症状。肠漏综合征的病因和病理生理学是多因素的；先前的胃肠道感染、炎症性肠病以及某些药物在一些患者中可能是相关因素。肠漏综合征的诊断存在问题。尽管患者经常被告知可以通过血液检查或粪便检查结果轻松做出诊断，但目前尚无经过验证的检测方法来进行这一诊断。患者对肠漏综合征的病因、诊断和治疗存在各种误解，这可能会引起恐慌，并常常导致昂贵、不必要的检查以及未经证实、有时甚至危险的治疗。本文回顾了一些关于肠漏综合征最常见的误解，并提供科学文献中的数据以纠正这些说法。如有可用数据，还会提供基于数据的管理策略。
