Pazyar Nader, Sananzadeh Sedigheh, Yaghoobi Reza, Bakhtiari Nima
Dermatology Department, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Pharmacology Department, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
World J Plast Surg. 2024;13(2):44-52. doi: 10.61186/wjps.13.2.44.
Hypertrophic scars and keloids are disorders caused by the excessive growth of connective tissue, associated with the accumulation of collagen and cellular matrix components. These scars are caused by abnormal wound healing and can have a great impact on patients' lives. Therefore, we aimed to compare the effect of intralesional injection of vitamin D with triamcinolone acetonide in the treatment of keloid.
This study was a one-sided blind clinical trial, conducted on 22 patients (44 samples) with keloid. It was a randomized, blinded clinical trial, conducted in Imam Khomeini Hospital in Ahvaz, Iran in 2022. In each group, triamcinolone or vitamin D was injected at the lesion site with an interval of three weeks and an average of 6 sessions. The patients were re-evaluated 3 months after the end of the treatment in terms of recurrence.
By examining the VSS scale in each of the groups, this scale decreased significantly in both groups after the intervention (P=0.001), which was greater in the group receiving triamcinolone (P=0.001).
It seems that the injection of vitamin D at the site of the lesion helps to treat it, but the effectiveness of the usual triamcinolone treatment was still higher, it is suggested to use vitamin D as an adjunctive treatment in these patients.
肥厚性瘢痕和瘢痕疙瘩是由结缔组织过度生长引起的疾病，与胶原蛋白和细胞基质成分的积累有关。这些瘢痕是由异常伤口愈合引起的，会对患者的生活产生很大影响。因此，我们旨在比较病灶内注射维生素D与曲安奈德治疗瘢痕疙瘩的效果。
本研究是一项单盲临床试验，对22例（44个样本）瘢痕疙瘩患者进行。这是一项随机、双盲临床试验，于2022年在伊朗阿瓦士的伊玛目霍梅尼医院进行。每组在病灶部位注射曲安奈德或维生素D，间隔3周，平均注射6次。治疗结束3个月后对患者的复发情况进行重新评估。
通过检查每组的VSS量表，干预后两组的该量表均显著下降（P=0.001），接受曲安奈德治疗的组下降幅度更大（P=0.001）。
似乎在病灶部位注射维生素D有助于治疗，但常规曲安奈德治疗的效果仍然更高，建议在这些患者中使用维生素D作为辅助治疗。
