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改善高位周围神经损伤的神经再生：兔模型中在损伤肢体最远端进行端端H形神经移植

Improved Neurotization in High Peripheral Nerve Injury: Side to Side H-shaped Nerve Graft at the Most Distal Part of an Injured Extremity in a Rabbit Model.

作者信息

Mozafari Naser, Yavari Masoud, Karimi Rouzbahani Arian, Mozafari Mohammad Ali, Mozafari Alireza, Beiranvand Siavash, Mahmoudvand Hormoz

机构信息

Department of Plastic Surgery, School of Medicine, Panzdahe Khordad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.

出版信息

World J Plast Surg. 2024;13(2):50-57. doi: 10.61186/wjps.13.2.50.

DOI:10.61186/wjps.13.2.50
PMID:39193240
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11346692/
Abstract

BACKGROUND

We aimed to investigate the effects of nerve repair by setting a side-to-side (H-shaped) nerve graft on the most distal part of the damaged nerve to the adjacent intact nerve to accelerate its regeneration in the end organ.

METHODS

This pure experimental study was done on the lower extremities of two groups of rabbits in Animal Laboratory Department, 15 Khordad Hospital Tehran, Iran. In both groups, the sciatic nerve at the proximal part of the extremity below the superficial femoral branch was first cut and then repaired. In the investigation group, side-to-side H-shaped nerve grafts were applied between the sciatic and superficial femoral nerves (i.e., two branches) at the most distal to the cut site of the sciatic nerve below the superficial femoral branch at the lower extremity. The sciatic nerve was conventionally repaired in the control group.

RESULTS

None of the rabbits' feet in the control group respond to pain stimulation (were without senses) and had ulcers. They had numb legs and went lame. All had muscular atrophy and lacked nerve growth (regeneration) according to pathology. In the investigation group, 86.7% of the rabbits responded to pain stimulation and only 13.3% of them had ulcers. In addition, in pathology report, 13.3% had suffered muscular atrophy and lacked nerve regeneration. Therefore, nerve regeneration was successful in 86.7% of rabbits who underwent H-shaped nerve grafts.

CONCLUSION

Side-to-side H-shaped nerve graft at the most distal part of an injured nerve may cause successful recovery of high (proximal) nerve injury.

摘要

背景

我们旨在通过在受损神经最远端与相邻完整神经之间设置端侧（H形）神经移植来研究神经修复的效果，以加速其在终末器官中的再生。

方法

这项纯实验研究在伊朗德黑兰科尔达德医院动物实验室的两组兔子下肢上进行。两组中，首先切断股浅支以下肢体近端的坐骨神经，然后进行修复。在研究组中，在下肢股浅支以下坐骨神经切断部位最远端的坐骨神经和股浅神经（即两个分支）之间应用端侧H形神经移植。对照组则常规修复坐骨神经。

结果

对照组中所有兔子的足部对疼痛刺激均无反应（失去感觉）且出现溃疡。它们腿部麻木且跛行。根据病理学检查，所有兔子均有肌肉萎缩且缺乏神经生长（再生）。在研究组中，86.7%的兔子对疼痛刺激有反应，只有13.3%的兔子出现溃疡。此外，在病理报告中，13.3%的兔子有肌肉萎缩且缺乏神经再生。因此，接受H形神经移植的兔子中有86.7%神经再生成功。

结论

在受损神经最远端进行端侧H形神经移植可能会使高位（近端）神经损伤成功恢复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bcb/11346692/5883e7f480cd/wjps-13-050-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bcb/11346692/a2c66d1b304f/wjps-13-050-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bcb/11346692/5883e7f480cd/wjps-13-050-g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bcb/11346692/9c3b64da5473/wjps-13-050-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bcb/11346692/cd95139ff83e/wjps-13-050-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bcb/11346692/1f4aae578dca/wjps-13-050-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bcb/11346692/47dd89374885/wjps-13-050-g007.jpg
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