Institute of EcoHealth, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of China.
State Key Laboratory of Pathogen and Biosecurity, AMMS, Beijing, People's Republic of China.
Emerg Microbes Infect. 2024 Dec;13(1):2396870. doi: 10.1080/22221751.2024.2396870. Epub 2024 Sep 5.
The continual emergence of tick-borne rickettsioses has garnered widespread global attention. Rickettsia barbariae ( R. barbariae), which emerged in Italy in 2008, has been detected in humans from northwestern China. However, the lack of R. barbariae genome and isolated strains limits the understanding of its biological characteristics and genomic features. Here, we isolated the for the first time from eggs of in northwestern China, and assembled its whole genome after next-generation sequencing, so we modified the proposed name to () to conform to the International Code of Nomenclature of Prokaryotes. Phylogenetic analysis based on the whole genome revealed that it was most closely related to the pathogenic and . All virulence factors, present in the pathogenic spotted fever group rickettsiae, were identified in the isolate. These findings highlight the pathogenic potential of and the necessity for enhanced surveillance of the emerging in the human population.
蜱传立克次体病的不断出现引起了全球广泛关注。2008 年在意大利出现的贝纳柯克斯体（R. barbariae）已在中国西北地区的人群中检测到。然而，由于缺乏 R. barbariae 基因组和分离株，限制了对其生物学特性和基因组特征的了解。在这里，我们首次从中国西北地区的硬蜱卵中分离出该菌，并通过下一代测序对其全基因组进行了组装，因此我们将提议的名称修改为（），以符合《国际原核生物命名法规》。基于全基因组的系统发育分析表明，它与致病性斑点热群立克次体最为密切相关。在分离株中发现了所有存在于致病性斑点热群立克次体中的毒力因子。这些发现突出了的致病性潜力以及加强对人群中新出现的监测的必要性。
