Tian Zhige, Li Tingjie, Fan Yuping, Li Jiayi, Luo Sirong, Cao Wanxin, Pan Qing, Hu Xiaoliang
Faculty of Agriculture, Forestry and Food Engineering, Yibin University, Yibin, China.
College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, China.
Front Microbiol. 2025 Jul 28;16:1590538. doi: 10.3389/fmicb.2025.1590538. eCollection 2025.
Papillomaviruses have been previously identified in mammals, avians and fish. However, few numbers of reptiles' PVs have been characterized.
This study investigated the oral cavity of the splendid japalure () in southwestern China using high-throughput sequencing. The presence of papillomavirus strain JsPV in oral samples was confirmed using PCR with consensus primers.
In this study, a papillomavirus strain, designated JsPV, in the oral cavity of the splendid japalure (Japalura splendida) in southwestern China. The complete JsPV genome was sequenced, comprising 222 bp. Phylogenetic analysis based on the L1 protein revealed that JsPV clustered closely with gecko-derived strains (HfrePV1 and HfrePV2) and other sauropsid-associated papillomaviruses, while remaining distinct from mammalian- and fish-associated lineages. These findings provide insights into the evolutionary origins of papillomaviruses in reptiles.
乳头瘤病毒此前已在哺乳动物、鸟类和鱼类中被发现。然而，已被鉴定特征的爬行动物乳头瘤病毒数量很少。
本研究利用高通量测序技术对中国西南部丽纹攀蜥（丽纹龙蜥）的口腔进行了调查。使用通用引物通过聚合酶链反应（PCR）证实了口腔样本中乳头瘤病毒JsPV株的存在。
在本研究中，在中国西南部丽纹攀蜥（丽纹龙蜥）的口腔中发现了一种乳头瘤病毒株，命名为JsPV。对JsPV的完整基因组进行了测序，其长度为222bp。基于L1蛋白的系统发育分析表明，JsPV与源自壁虎的毒株（HfrePV1和HfrePV2）以及其他与蜥形纲相关的乳头瘤病毒紧密聚类，同时与哺乳动物和鱼类相关的谱系明显不同。这些发现为爬行动物乳头瘤病毒的进化起源提供了见解。
