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Prostaglandins act synergistically with antitumour agents on induction of sister chromatid exchanges in human lymphocytes.

作者信息

Dozi-Vassiliades J, Mourelatos D

出版信息

Prostaglandins Leukot Med. 1985 Jan;17(1):55-9. doi: 10.1016/0262-1746(85)90033-2.

Abstract

Prostaglandins (PGs) E1 and E2 were found to enhance Sister Chromatid Exchange (SCE) frequencies induced by Mitomycin C (MMC) or Melphalan (ME-LPH) in cultured normal human lymphocytes. PG E1, E2 and F2a alone had no effect on SCE induction up to the higher concentration tested of 2 micrograms/ml. PG F2a does not act synergistically with MELPH on induction of SCEs.

摘要

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