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单独使用维生素A或与美法仑及咖啡因联合使用对人淋巴细胞姐妹染色单体交换及细胞周期延迟的诱导作用。

Induction of sister-chromatid exchanges and cell-cycle delays in human lymphocytes by vitamin A alone or in combination with melphalan and caffeine.

作者信息

Dozi-Vassiliades J, Myrtsiotis A, Granitsas A, Mourelatos D

出版信息

Eur J Cancer Clin Oncol. 1985 Sep;21(9):1089-92. doi: 10.1016/0277-5379(85)90296-2.

DOI:10.1016/0277-5379(85)90296-2
PMID:4065180
Abstract

In cultured human lymphocytes vitamin A was found to increase SCE rates, to reduce the mitotic index and to have no effect on cell kinetics. Vitamin A induces cytotoxic effects: in combination with melphalan (MELPH), as can be deduced from the resulted synergism on induction of SCEs, the produced cell division delay and the suppressed mitotic index; in combination with caffeine (CAF), producing synergism on induction of SCEs and suppressing the mitotic index; and in combination with MELPH and CAF, producing cell-cycle delays and reducing the mitotic index.

摘要

在培养的人淋巴细胞中，发现维生素A可提高姐妹染色单体交换率、降低有丝分裂指数且对细胞动力学无影响。维生素A可诱导细胞毒性作用：与美法仑（MELPH）联合使用时，从对姐妹染色单体交换诱导的协同作用、产生的细胞分裂延迟以及抑制的有丝分裂指数可以推断出；与咖啡因（CAF）联合使用时，对姐妹染色单体交换诱导产生协同作用并抑制有丝分裂指数；与美法仑和咖啡因联合使用时，产生细胞周期延迟并降低有丝分裂指数。

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