Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
Eur Rev Med Pharmacol Sci. 2024 Aug;28(15):4046-4059. doi: 10.26355/eurrev_202408_36636.
A metabolism score for visceral fat (METS-VF) is an innovative method to access abdominal fat and visceral fat. So far, the relationship between the METS-VF index and chronic obstructive pulmonary disease (COPD) has remained unclear. We investigated the relationship between the METS-VF index and COPD prevalence utilizing data from the National Health and Nutrition Examination Survey (NHANES) 2007-2018.
A binary logistic regression analysis was performed using NHANES 2007-2018 data to assess the relationship between the METS-VF index and COPD prevalence. The relationship was verified by fitted smooth curves, generalized additive models, threshold effect analyses, subgroup analyses, and sensitivity analyses.
In total, 7,680 subjects were recruited for the study, including 772 self-reported having COPD. The METS-VF index was positively related to COPD prevalence when adjusted for all covariates. The METS-VF index was classified by quartiles, and participants who scored highest on METS-VF were at a greater risk of COPD than those who scored lowest. According to a threshold effect analysis, the METS-VF index was negatively correlated with COPD prevalence with a METS-VF index <7.00, without statistical significance. Once the METS-VF index exceeded 7.00, there was a robust positive correlation between the METS-VF index and COPD prevalence. In the analysis of subgroups, the METS-VF index was positively correlated with COPD prevalence among subjects who were male, aged 40-59, and without asthma or hypertension. The results were robust in sensitivity analyses. METS-VF showed a significantly better diagnostic value for COPD than Body Mass Index (BMI).
The METS-VF index has a non-linear and positive correlation with COPD prevalence in the middle-aged and elderly American population.
内脏脂肪代谢评分（METS-VF）是一种评估腹部脂肪和内脏脂肪的创新方法。到目前为止，METS-VF 指数与慢性阻塞性肺疾病（COPD）之间的关系尚不清楚。我们利用 2007-2018 年国家健康和营养检查调查（NHANES）的数据，研究了 METS-VF 指数与 COPD 患病率之间的关系。
使用 NHANES 2007-2018 年的数据进行二元逻辑回归分析，以评估 METS-VF 指数与 COPD 患病率之间的关系。通过拟合平滑曲线、广义加性模型、阈值效应分析、亚组分析和敏感性分析来验证这种关系。
共有 7680 名受试者被纳入研究，其中 772 名自我报告患有 COPD。在调整所有协变量后，METS-VF 指数与 COPD 患病率呈正相关。METS-VF 指数按四分位法分类，METS-VF 得分最高的参与者患 COPD 的风险高于得分最低的参与者。根据阈值效应分析，METS-VF 指数与 COPD 患病率呈负相关，当 METS-VF 指数<7.00 时，无统计学意义。一旦 METS-VF 指数超过 7.00，METS-VF 指数与 COPD 患病率之间就存在显著的正相关。在亚组分析中，在男性、40-59 岁、无哮喘或高血压的受试者中，METS-VF 指数与 COPD 患病率呈正相关。敏感性分析结果稳健。METS-VF 对 COPD 的诊断价值明显优于体质指数（BMI）。
在中年和老年美国人群中，METS-VF 指数与 COPD 患病率呈非线性正相关。
