Pang Boqi, Xian Jiaru, Chen Jiajun, Ng Liqi, Li Mengting, Zhao Guangchun, E Yixun, Wang Xiaorui, Cao Xiaxin, Zhang Changze, Zhang Mingjing, Liu Chaozong
Hainan Provincial Fine Chemical Engineering Research Center, Hainan University, Haikou 570228, China.
Institute of Orthopaedic & Musculoskeletal Science, University College London, Royal National Orthopaedic Hospital, London HA7 4LP, UK.
J Funct Biomater. 2024 Jul 29;15(8):212. doi: 10.3390/jfb15080212.
Cuttlefish bones are byproducts of cuttlefish processing and are readily available in the marine food industry. In this study, calcium phosphate bioceramics were prepared from cuttlefish bones using a two-stage hydrothermal calcination process. The results indicated that all bioceramics derived from cuttlefish bones had a higher degradation capacity, better bone-like apatite formation ability, and higher degree of osteogenic differentiation than commercially available hydroxyapatite. Notably, β-tricalcium phosphate, which had the highest degree of Ca and Sr dissolution among the bioceramics extracted, can significantly upregulate osteogenic markers (alkaline phosphatase, osteocalcin) and stimulate bone matrix mineralization. Thus, it is a promising bioceramic material for applications in bone regeneration.
乌贼骨是乌贼加工的副产品，在海洋食品工业中很容易获得。在本研究中，采用两步水热煅烧工艺从乌贼骨中制备了磷酸钙生物陶瓷。结果表明，所有源自乌贼骨的生物陶瓷都具有比市售羟基磷灰石更高的降解能力、更好的类骨磷灰石形成能力和更高的成骨分化程度。值得注意的是，在所提取的生物陶瓷中，钙和锶溶解程度最高的β - 磷酸三钙能够显著上调成骨标志物（碱性磷酸酶、骨钙素）并刺激骨基质矿化。因此，它是一种在骨再生应用中很有前景的生物陶瓷材料。
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