Palomar-Gallego María Angustias, Ramiro-Bargueño Julio, Cuerda-Galindo Esther, Linares-García-Valdecasas Rafael, Gómez-Sánchez Stella M, Delcan José, Díaz-Gil Gema
Department of Basic Health Sciences, Universidad Rey Juan Carlos, 28922 Alcorcón, Spain.
Grupo de Investigación Emergente de Bases Anatómicas, Moleculares y del Desarrollo Humano de la Universidad Rey Juan Carlos (GAMDES), 28922 Alcorcón, Spain.
Curr Issues Mol Biol. 2024 Jul 25;46(8):7986-7996. doi: 10.3390/cimb46080472.
Lipoatrophia semicircularis is a benign pathology characterized by subcutaneous tissue atrophy that affects the skin and related structures. Its etiology remains unclear; however, in the recent few years, it has been proposed that electrostatic charges could be a potential factor. Based on this hypothesis, the aim of this work is to study the cause-effect relation between electrostatic energy and LS, providing insights into the molecular mechanisms. For this purpose, an experimental murine model was created using obese mice. One group served as a control and the other groups involved charging clothes with varying connections to the ground: through the skin, through the clothes or not connected to the ground). Skin biopsies showed that the most significant lesions, including lipophagic granulomas with inflammatory infiltrate, were found in the first group (connected to the ground through the skin). Lipophagic reactions without an inflammatory infiltrate were observed in the other groups subjected to electrical discharges. In the control mice, no histological changes were observed. Oxidative processes were also measured in lower limbs tissue. Malondialdehyde levels significantly increased in the lower limbs after electrostatic discharges. However, the presence of ground through a wire attached to highly conductive clothes around the thigh significantly reduced the effect of electrostatic charges on lipid peroxidation. To our knowledge, this is the first study in which an experimental model has been used to reproduce LS induced by electrostatic energy, suggesting a cause-effect relationship between electrostatic charge and discharge with fat tissue lesion.
半圆形脂肪萎缩是一种良性病变，其特征为皮下组织萎缩，累及皮肤及相关结构。其病因尚不清楚；然而，近年来有人提出静电荷可能是一个潜在因素。基于这一假设，本研究旨在探讨静电能量与半圆形脂肪萎缩之间的因果关系，深入了解其分子机制。为此，利用肥胖小鼠建立了一个实验性小鼠模型。一组作为对照组，其他组则将衣物与地面以不同方式连接（通过皮肤、通过衣物或不与地面连接）。皮肤活检显示，在第一组（通过皮肤与地面连接）中发现了最显著的病变，包括伴有炎症浸润的噬脂性肉芽肿。在其他遭受放电的组中观察到了无炎症浸润的噬脂反应。在对照小鼠中，未观察到组织学变化。还对下肢组织中的氧化过程进行了测量。静电放电后，下肢丙二醛水平显著升高。然而，通过连接在大腿周围高导电性衣物上的导线接地，可显著降低静电荷对脂质过氧化的影响。据我们所知，这是第一项使用实验模型来重现由静电能量诱导的半圆形脂肪萎缩的研究，表明静电荷与放电和脂肪组织病变之间存在因果关系。
