Jones S M, Winter A J
Department of Microbiology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853.
Infect Immun. 1992 Jul;60(7):3011-4. doi: 10.1128/iai.60.7.3011-3014.1992.
Virulent Brucella abortus 2308 was phagocytized more readily than attenuated strain 19 following opsonization and survived at significantly higher levels in normal murine peritoneal macrophages and in macrophages treated with gamma interferon. Activation of macrophages with gamma interferon greatly inhibited intracellular replication of strain 2308 but did not result in its elimination. These data support the hypothesis that persistent infection of the host requires the ability of antibody-opsonized B. abortus to survive in activated macrophages.
在进行调理作用后，强毒株布鲁氏菌流产杆菌2308比减毒株19更容易被吞噬，并且在正常小鼠腹腔巨噬细胞和经γ干扰素处理的巨噬细胞中存活水平显著更高。用γ干扰素激活巨噬细胞极大地抑制了2308菌株的细胞内复制，但并未导致其被清除。这些数据支持了这样的假说，即宿主的持续感染需要抗体调理的流产布鲁氏菌在活化巨噬细胞中存活的能力。
