Atia Hanan Abdelmawgoud, Shahien Mona M, Ibrahim Somaia, Ahmed Enas Haridy, Elariny Hemat A, Abdallah Marwa H
Department of Pharmacology and Toxicology, College of Pharmacy, University of Ha'il, Ha'il 81442, Saudi Arabia.
Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Cairo 11651, Egypt.
Gels. 2024 Aug 10;10(8):525. doi: 10.3390/gels10080525.
Inflammation is a vascular response that occurs when the immune system responds to a range of stimuli including viruses, allergens, damaged cells, and toxic substances. Inflammation is accompanied by redness, heat, swelling, discomfort, and loss of function. Natural products have been shown to have considerable therapeutic benefits, and they are increasingly being regarded as feasible alternatives for clinical preventative, diagnostic, and treatment techniques. Natural products, in contrast to developed medications, not only contain a wide variety of structures, they also display a wide range of biological activities against a variety of disease states and molecular targets. This makes natural products appealing for development in the field of medicine. In spite of the progress that has been made in the application of natural products for clinical reasons, there are still factors that prevent them from reaching their full potential, including poor solubility and stability, as well limited efficacy and bioavailability. In order to address these problems, transdermal nanovesicular gel systems have emerged as a viable way to overcome the hurdles that are encountered in the therapeutic use of natural products. These systems have a number of significant advantages, including the ability to provide sustained and controlled release, a large specific surface area, improved solubility, stability, increased targeting capabilities and therapeutic effectiveness. Further data confirming the efficacy and safety of nanovesicles-gel systems in delivering natural products in preclinical models has been supplied by extensive investigations conducted both in vitro and in vivo. This study provides a summary of previous research as well as the development of novel nanovesicular gel formulations and their application through the skin with a particular emphasis on natural products used for treatment of inflammation.
炎症是一种血管反应，当免疫系统对包括病毒、过敏原、受损细胞和有毒物质在内的一系列刺激作出反应时就会发生。炎症会伴有发红、发热、肿胀、不适和功能丧失。天然产物已被证明具有相当大的治疗益处，并且它们越来越被视为临床预防、诊断和治疗技术的可行替代方案。与已开发的药物相比，天然产物不仅包含各种各样的结构，它们还针对多种疾病状态和分子靶点表现出广泛的生物活性。这使得天然产物在医学领域具有开发吸引力。尽管在将天然产物用于临床方面已经取得了进展，但仍有一些因素阻碍它们充分发挥潜力，包括溶解度和稳定性差，以及疗效和生物利用度有限。为了解决这些问题，透皮纳米囊泡凝胶系统已成为克服天然产物治疗应用中遇到的障碍的可行方法。这些系统具有许多显著优点，包括能够提供持续和控释、大的比表面积、改善的溶解度、稳定性、增强的靶向能力和治疗效果。体外和体内进行的广泛研究提供了进一步的数据，证实了纳米囊泡 - 凝胶系统在临床前模型中递送天然产物的有效性和安全性。本研究总结了先前的研究以及新型纳米囊泡凝胶制剂的开发及其经皮应用，特别强调用于治疗炎症的天然产物。
