Student Research Group of Microbiology and Immunology, Department of Microbiology and Immunology, Zabrze, Medical University of Silesia in Katowice, 40-055 Katowice, Poland.
Student Research Group of Internal Medicine and Allergology, Clinical Department of Internal Medicine, Pneumology and Allergology, Wroclaw Medical University, 50-369 Wrocław, Poland.
Cells. 2024 Aug 22;13(16):1398. doi: 10.3390/cells13161398.
Atopic dermatitis (AD) is a prevalent and chronic inflammatory skin condition characterized by a multifaceted pathophysiology that gives rise to diverse clinical manifestations. The management of AD remains challenging due to the suboptimal efficacy of existing treatment options. Nonetheless, recent progress in elucidating the underlying mechanisms of the disease has facilitated the identification of new potential therapeutic targets and promising drug candidates. In this review, we summarize the newest data, considering multiple connections between IL-22 and AD. The presence of circulating IL-22 has been found to correlate with the severity of AD and is identified as a critical factor driving the inflammatory response associated with the condition. Elevated levels of IL-22 in patients with AD are correlated with increased proliferation of keratinocytes, alterations in the skin microbiota, and impaired epidermal barrier function. Collectively, these factors contribute to the manifestation of the characteristic symptoms observed in AD.
特应性皮炎（AD）是一种常见的慢性炎症性皮肤病，其病理生理学具有多方面的特点，导致了不同的临床表现。由于现有治疗方案的疗效不理想，AD 的治疗仍然具有挑战性。然而，近年来对疾病潜在机制的研究进展促进了新的潜在治疗靶点和有前途的药物候选物的鉴定。在这篇综述中，我们总结了最新的数据，考虑了 IL-22 与 AD 之间的多种联系。循环中 IL-22 的存在与 AD 的严重程度相关，并被确定为驱动与该疾病相关的炎症反应的关键因素。AD 患者中 IL-22 水平升高与角质形成细胞增殖增加、皮肤微生物群改变和表皮屏障功能受损有关。这些因素共同导致了 AD 特征性症状的表现。
