Pathirathna Malshani Lakshika, Haruna Megumi, Sasaki Satoshi, Yonezawa Kaori, Usui Yuriko, Hagiwara Yasuhiro
Department of Midwifery and Women's Health, Division of Health Sciences and Nursing, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Department of Nursing, Faculty of Allied Health Sciences, University of Peradeniya, Peradeniya 20400, Sri Lanka.
Methods Protoc. 2024 Aug 6;7(4):61. doi: 10.3390/mps7040061.
Perinatal cohort studies with a prospective longitudinal design are critical for determining the effects of early-life exposures on offspring's health outcomes. The Sri Lanka Mother and Newborn Growth cohort study aims to investigate the impact of maternal nutritional and psychosocial factors on newborns' birth weight in the Sri Lankan context. This paper presents the methodology of participant recruitment, follow-ups, an overview of measurements, and planned data analyses. This study included a nationally representative sample of Sri Lankan pregnant women recruited in their first trimester of pregnancy. Follow-up assessments were conducted once during the second and third trimesters of pregnancy and after the baby's birth, prospectively tracking the women's dietary intake, mental health, hemoglobin concentrations, and gestational weight gain data. Once the participants delivered their babies, the data on gestational age, sex of the newborn, birth weight, length and occipitofrontal circumference at birth, and mode of delivery were collected. Between August 2022 and August 2023, we recruited 2000 first-trimester pregnant women to the cohort and continued to follow up with them until the baby's birth. The response rates were 90.4%, 81.4%, and 75.2% in the first, second, and third follow-ups. We plan to analyze the data in July 2024. We expect this study to provide valuable insights into various early-life exposures affecting neonatal birth weight. The study's findings will serve as a valuable information resource for a broader scientific community, enabling the development of effective policies to prevent low-birth-weight deliveries in low-resource settings.
采用前瞻性纵向设计的围产期队列研究对于确定早期暴露对后代健康结局的影响至关重要。斯里兰卡母婴生长队列研究旨在调查在斯里兰卡背景下，母亲的营养和心理社会因素对新生儿出生体重的影响。本文介绍了参与者招募、随访、测量概述以及计划进行的数据分析方法。本研究纳入了在妊娠早期招募的具有全国代表性的斯里兰卡孕妇样本。在妊娠中期和晚期以及婴儿出生后各进行一次随访评估，前瞻性地跟踪这些女性的饮食摄入、心理健康、血红蛋白浓度和孕期体重增加数据。一旦参与者分娩，就收集有关胎龄、新生儿性别、出生体重、出生时的身长和枕额周长以及分娩方式的数据。在2022年8月至2023年8月期间，我们招募了2000名妊娠早期孕妇进入该队列，并持续对她们进行随访直至婴儿出生。第一次、第二次和第三次随访的应答率分别为90.4%、81.4%和75.2%。我们计划在2024年7月分析数据。我们期望这项研究能为影响新生儿出生体重的各种早期暴露提供有价值的见解。该研究的结果将成为更广泛科学界的宝贵信息资源，有助于制定有效政策，以防止资源匮乏地区出现低体重儿分娩情况。
