Faculty of Medicine and Health, Central Clinical School, The University of Sydney, Sydney, New South Wales, Australia
The University of Sydney Charles Perkins Centre, Sydney, New South Wales, Australia.
BMJ Open. 2023 Jun 8;13(6):e068275. doi: 10.1136/bmjopen-2022-068275.
The health of parents prior to conception, a woman's health during pregnancy and the infant's environment across their first months and years collectively have profound effects on the child's health across the lifespan. Since there are very few cohort studies in early pregnancy, gaps remain in our understanding of the mechanisms underpinning these relationships, and how health may be optimised. 'BABY1000', a pilot prospective longitudinal birth cohort study, aims to (1) identify factors before and during pregnancy and early life that impact longer-term health and (2) assess the feasibility and acceptability of study design to inform future research.
Participants were based in Sydney, Australia. Women were recruited at preconception or 12 weeks' gestation, and data were collected from them throughout pregnancy and postpartum, their children until the age of 2 years, and dietary information from a partner (if able) at the last study visit. The pilot aimed to recruit 250 women. However, recruitment ceased earlier than planned secondary to limitations from the COVID-19 pandemic and the final number of subjects was 225.
Biosamples, clinical measurements and sociodemographic/psychosocial measures were collected using validated tools and questionnaires. Data analysis and 24-month follow-up assessments for children are ongoing. Key early findings presented include participant demographics and dietary adequacy during pregnancy. The COVID-19 pandemic and associated public health and research restrictions affected recruitment of participants, follow-up assessments and data completeness.
The BABY1000 study will provide further insight into the developmental origins of health and disease and inform design and implementation of future cohort and intervention studies in the field. Since the BABY1000 pilot was conducted across the COVID-19 pandemic, it also provides unique insight into the early impacts of the pandemic on families, which may have effects on health across the lifespan.
父母在受孕前的健康状况、女性在怀孕期间的健康状况以及婴儿在头几个月和几年内的环境，都会对其整个生命周期的健康产生深远影响。由于在早孕阶段几乎没有队列研究，因此我们对于这些关系背后的机制以及如何优化健康状况的理解仍存在差距。“BABY1000”是一项前瞻性纵向出生队列研究的试点研究，旨在：(1) 确定怀孕前和怀孕早期以及生命早期影响长期健康的因素；(2) 评估研究设计的可行性和可接受性，以为未来的研究提供信息。
参与者来自澳大利亚悉尼。女性在受孕前或 12 周妊娠时被招募，研究人员在整个怀孕期间和产后、孩子 2 岁前以及在最后一次研究访问时（如果可能）从伴侣那里收集数据。该试点研究旨在招募 250 名女性。然而，由于 COVID-19 大流行的限制，招募工作提前停止，最终的研究对象为 225 名。
使用经过验证的工具和问卷收集了生物样本、临床测量值以及社会人口统计学/心理社会测量值。数据分析和儿童 24 个月的随访评估正在进行中。目前已呈现的主要早期发现包括参与者的人口统计学特征和怀孕期的饮食充足性。COVID-19 大流行及其相关的公共卫生和研究限制影响了参与者的招募、随访评估和数据完整性。
BABY1000 研究将提供更多关于健康与疾病发育起源的信息，并为该领域的未来队列研究和干预研究的设计和实施提供信息。由于 BABY1000 试点研究是在 COVID-19 大流行期间进行的，因此它还提供了有关大流行对家庭的早期影响的独特见解，这可能会对整个生命周期的健康产生影响。
