Seo Eunhye, Kwon Yeongkeun, Park Sungsoo
College of Nursing, Keimyung University, Daegu 42601, Republic of Korea.
Department of Surgery, Division of Foregut Surgery, Korea University College of Medicine, Seoul 02841, Republic of Korea.
Metabolites. 2024 Aug 11;14(8):444. doi: 10.3390/metabo14080444.
Sleeve gastrectomy typically leads to weight loss, including a reduction in fat-free mass (FFM). Studies have shown significant FFM loss within 1 year after the procedure but with individual variations. This study aimed to assess whether preoperative amino acid metabolite levels can predict FFM changes following sleeve gastrectomy. This study involved 42 patients. Body weight, fat mass (FM), and FFM were measured preoperatively and 3, 6, and 12 months postoperatively. All participants experienced weight loss, FM reduction, and FFM decrease for up to 3 months after surgery. However, the following distinct groups emerged from 3 to 6 months postoperatively: one showed FFM gain relative to weight loss, whereas the other exhibited continued FFM reduction relative to weight loss. This trend persisted for up to 12 months postoperatively and became more pronounced. The group with FFM gain had lower preoperative BMI and higher levels of indole-3-pyruvic acid (IPyA). Logistic regression and ROC curve analyses confirmed IPyA's ability to predict FFM gain between 3 and 6 months after sleeve gastrectomy, with a useful cutoff value of 20.205. Preoperative IPyA levels were associated with FFM gain relative to weight loss in the 3 to 6 months following sleeve gastrectomy. These findings suggest that IPyA may be a potential predictor for FFM changes during this period.
袖状胃切除术通常会导致体重减轻，包括去脂体重（FFM）的减少。研究表明，手术后1年内FFM会有显著损失，但存在个体差异。本研究旨在评估术前氨基酸代谢物水平是否可以预测袖状胃切除术后FFM的变化。本研究纳入了42例患者。在术前以及术后3、6和12个月测量体重、脂肪量（FM）和FFM。所有参与者在术后3个月内均出现体重减轻、FM减少和FFM下降。然而，术后3至6个月出现了以下不同的组：一组相对于体重减轻表现为FFM增加，而另一组相对于体重减轻则表现为FFM持续减少。这种趋势在术后长达12个月内持续存在且更加明显。FFM增加的组术前BMI较低且吲哚-3-丙酮酸（IPyA）水平较高。逻辑回归和ROC曲线分析证实IPyA能够预测袖状胃切除术后3至6个月的FFM增加，有效临界值为20.205。术前IPyA水平与袖状胃切除术后3至6个月相对于体重减轻的FFM增加相关。这些发现表明，IPyA可能是这一时期FFM变化的潜在预测指标。
