Stanway G W, Taylor P M, Brodbelt D C
Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge, UK.
Vet Anaesth Analg. 2002 Jan;29(1):29-35. doi: 10.1046/j.1467-2987.2001.00062.x. Epub 2016 Nov 15.
To compare the postoperative analgesic and sedative properties of buprenorphine and morphine in cats.
Prospective, randomized, blinded study.
Thirty-two domestic cats undergoing surgery.
Cats received pre-anaesthetic medication with acepromazine (0.05 mg kg) given intramuscularly and were randomly allocated to group M and given morphine (0.1 mg kg) intramuscularly (IM) or to group B and given buprenorphine (0.01 mg kg) IM. Anaesthesia was induced with propofol and maintained with halothane in oxygen and nitrous oxide. Pain and sedation scores using visual analogue scales, and heart and respiratory rates, were measured immediately before, and 30, 60, 120, 180, 300 and 420 minutes after anaesthesia.
Pain scores were significantly lower at 60, 120 and 180 minutes after anaesthesia in group B. Group B also had higher heart rates at 30 minutes. There were no other statistically significant differences between the groups.
Buprenorphine (0.01 mg kg) appeared to provide better postoperative analgesia than morphine (0.1 mg kg) and may also have a longer duration of action.
比较丁丙诺啡和吗啡对猫的术后镇痛及镇静效果。
前瞻性、随机、双盲研究。
32只接受手术的家猫。
猫术前肌肉注射乙酰丙嗪（0.05毫克/千克），随机分为M组，肌肉注射吗啡（0.1毫克/千克）或B组，肌肉注射丁丙诺啡（0.01毫克/千克）。用丙泊酚诱导麻醉，并用氧气和氧化亚氮中的氟烷维持麻醉。在麻醉前、麻醉后30、60、120、180、300和420分钟，使用视觉模拟量表测量疼痛和镇静评分，以及心率和呼吸频率。
B组在麻醉后60、120和180分钟时疼痛评分显著较低。B组在30分钟时心率也较高。两组之间没有其他统计学上的显著差异。
丁丙诺啡（0.01毫克/千克）似乎比吗啡（0.1毫克/千克）提供更好的术后镇痛效果，并且作用持续时间可能更长。
