Garcea N, Campo S, Panetta V, Venneri M, Siccardi P, Dargenio R, De Tomasi F
Am J Obstet Gynecol. 1985 Mar 1;151(5):635-40. doi: 10.1016/0002-9378(85)90154-1.
Purified urinary follicle-stimulating hormone was used to induce ovulation in 18 patients with polycystic ovarian syndrome. Each ampule contained 75 IU of follicle-stimulating hormone and less than 0.11 IU of luteinizing hormone. Initial doses were 150 to 225 IU/day, later increased to a maximum of 375 IU, according to daily clinical controls and estradiol values. After 12 to 16 days, follicle-stimulating hormone treatment was suspended. Within 36 to 48 hours each patient received 5000 or 10,000 IU of human chorionic gonadotropin, rarely more. Ovulation occurred in 39 of 43 treatment cycles and hyperstimulation in nine. Seven patients had normal pregnancies with viable fetuses, including one pair of twins. Two had abortions. Analysis of the endocrine situation during therapy does not permit either pregnancy or hyperstimulation to be predicted. However, hyperstimulation is frequently accompanied by endogenous luteinizing hormone peaks and greater estradiol increases during the final phase of induction. Purified follicle-stimulating hormone has thus demonstrated its validity in inducing ovulation in patients with polycystic ovarian syndrome, apparently with equal or lower risks of hyperstimulation than with other gonadotropin preparations.
使用纯化的尿促卵泡素对18例多囊卵巢综合征患者进行促排卵治疗。每安瓿含75国际单位促卵泡素和少于0.11国际单位促黄体素。初始剂量为150至225国际单位/天，随后根据每日临床监测和雌二醇值最多增至375国际单位。12至16天后，暂停促卵泡素治疗。在36至48小时内，每位患者接受5000或10000国际单位人绒毛膜促性腺激素，很少超过此剂量。43个治疗周期中有39个发生排卵，9个出现卵巢过度刺激综合征。7例患者正常妊娠并怀有存活胎儿，其中包括一对双胞胎。2例流产。治疗期间的内分泌情况分析无法预测妊娠或卵巢过度刺激综合征的发生。然而，卵巢过度刺激综合征常伴有内源性促黄体素峰值以及诱导末期雌二醇水平更大幅度的升高。因此，纯化的促卵泡素已证明其在多囊卵巢综合征患者促排卵中的有效性，其卵巢过度刺激综合征的风险显然与其他促性腺激素制剂相当或更低。
