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Rescue of EndMT-associated endothelial dysfunction by modulating the YAP pathway.

作者信息

Bae Seongho, Jung Cholomi, Yoon Young-Sup

机构信息

Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA.

Department of Internal Medicine, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea.

出版信息

Nat Cardiovasc Res. 2023 May;2(5):420-422. doi: 10.1038/s44161-023-00268-0.

DOI:10.1038/s44161-023-00268-0
PMID:39196047
Abstract
摘要

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Nature. 2021 Apr;592(7855):524-533. doi: 10.1038/s41586-021-03392-8. Epub 2021 Apr 21.
2
Calpain Inhibition Restores Autophagy and Prevents Mitochondrial Fragmentation in a Human iPSC Model of Diabetic Endotheliopathy.钙蛋白酶抑制可恢复自噬并防止糖尿病血管内皮病变的人诱导多能干细胞模型中的线粒体碎片化。
Stem Cell Reports. 2019 Mar 5;12(3):597-610. doi: 10.1016/j.stemcr.2019.01.017. Epub 2019 Feb 21.
3
Large-Scale Single-Cell RNA-Seq Reveals Molecular Signatures of Heterogeneous Populations of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells.
大规模单细胞 RNA-Seq 揭示了人诱导多能干细胞衍生的内皮细胞异质群体的分子特征。
Circ Res. 2018 Aug 3;123(4):443-450. doi: 10.1161/CIRCRESAHA.118.312913.
4
Reassessing endothelial-to-mesenchymal transition in cardiovascular diseases.重新评估心血管疾病中的内皮细胞向间充质细胞转化。
Nat Rev Cardiol. 2018 Aug;15(8):445-456. doi: 10.1038/s41569-018-0023-y.
5
Endothelial-mesenchymal transition in atherosclerosis.动脉粥样硬化中的血管内皮-间充质转化。
Cardiovasc Res. 2018 Mar 15;114(4):565-577. doi: 10.1093/cvr/cvx253.
6
Pleiotropic and Adverse Effects of Statins-Do Epigenetics Play a Role?他汀类药物的多效性和不良反应——表观遗传学起作用吗？
J Pharmacol Exp Ther. 2017 Aug;362(2):319-326. doi: 10.1124/jpet.117.242081. Epub 2017 Jun 2.
7
Huntington's Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits.亨廷顿舞蹈病诱导多能干细胞衍生的脑微血管内皮细胞揭示了WNT介导的血管生成和血脑屏障缺陷。
Cell Rep. 2017 May 16;19(7):1365-1377. doi: 10.1016/j.celrep.2017.04.021.
8
Patient-Specific iPSC-Derived Endothelial Cells Uncover Pathways that Protect against Pulmonary Hypertension in BMPR2 Mutation Carriers.患者特异性诱导多能干细胞衍生的内皮细胞揭示了BMPR2突变携带者中预防肺动脉高压的途径。
Cell Stem Cell. 2017 Apr 6;20(4):490-504.e5. doi: 10.1016/j.stem.2016.08.019. Epub 2016 Dec 22.
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Circulation. 2011 Sep 6;124(10):1138-50. doi: 10.1161/CIRCULATIONAHA.110.005249. Epub 2011 Aug 15.