Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health.
Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland.
J Hypertens. 2024 Oct 1;42(10):1823-1830. doi: 10.1097/HJH.0000000000003828. Epub 2024 Aug 1.
The Dietary Approaches to Stop Hypertension (DASH) diet reduces blood pressure, but the mechanisms underlying DASH diet-blood pressure relations are not well understood. Proteomic measures may provide insights into the pathophysiological mechanisms through which the DASH diet reduces blood pressure.
The DASH (1994-1996) and DASH-Sodium (1997-1999) trials were multicenter, randomized-controlled feeding trials. Proteomic profiling was conducted in serum collected at the end of the feeding period (DASH, N = 215; DASH-Sodium, N = 390). Multivariable linear regression models were used to identify interactions between 71 DASH diet-related proteins and changes in systolic and diastolic blood pressure. Estimates were meta-analyzed across both trials. Elastic net models were used to identify proteins that predict changes in blood pressure.
Ten significant interactions were identified [systolic blood pressure: seven proteins; diastolic blood pressure: three proteins], which represented nine unique proteins. A high level of renin at the end of the feeding period was associated with greater reductions in diastolic blood pressure in individuals consuming the control than DASH diets. A high level of procollagen c-endopeptidase enhancer 1 (PCOLCE) and collagen triple helix repeat-containing protein 1 (CTHRC1) were associated with greater reductions in systolic blood pressure in individuals consuming the DASH than control diets, and with elevations in systolic blood pressure in individuals consuming the control diets (P for interaction for all tests < 0.05). Elastic net models identified six additional proteins that predicted change in blood pressure.
Several novel proteins were identified that may provide some insight into the relationship between the DASH diet and blood pressure.
膳食限制高血压（DASH）饮食可降低血压，但 DASH 饮食与血压关系的机制尚不清楚。蛋白质组学测量可能为 DASH 饮食降低血压的病理生理机制提供深入了解。
DASH（1994-1996 年）和 DASH-钠（1997-1999 年）试验是多中心、随机对照喂养试验。在喂养期结束时（DASH，N=215；DASH-钠，N=390）采集血清进行蛋白质组学分析。采用多变量线性回归模型，确定 71 种与 DASH 饮食相关的蛋白质与收缩压和舒张压变化之间的相互作用。对两项试验进行荟萃分析。弹性网络模型用于识别可预测血压变化的蛋白质。
鉴定出 10 个显著的相互作用[收缩压：7 种蛋白质；舒张压：3 种蛋白质]，代表 9 种独特的蛋白质。在喂养期结束时，肾素水平较高与接受对照饮食而非 DASH 饮食的个体舒张压降低幅度较大相关。高水平的前胶原 C 端肽酶增强子 1（PCOLCE）和三螺旋重复胶原蛋白 1（CTHRC1）与接受 DASH 饮食而非对照饮食的个体收缩压降低幅度较大相关，与接受对照饮食的个体收缩压升高相关（所有检验的交互作用 P 值均<0.05）。弹性网络模型确定了另外 6 种可预测血压变化的蛋白质。
鉴定出几种新的蛋白质，它们可能为 DASH 饮食与血压之间的关系提供一些见解。
