Khan Sara, Ahsan Farogh, Mahmood Tarique, Bano Shahzadi
Department of Pharmacy, Integral University, Kursi Road, Dasauli, Lucknow, Uttar Pradesh, 226026, India.
Department of Chemistry, Integral University, Kursi Road, Dasauli, Lucknow, Uttar Pradesh, 226026, India.
Chem Biodivers. 2024 Dec;21(12):e202401378. doi: 10.1002/cbdv.202401378. Epub 2024 Oct 28.
Anogeissus latifolia, commonly known as Axlewood, Indian Gum Tree, or Gum Ghatti, belongs to the Combretaceae family and is native to India, Nepal, Myanmar, and Sri Lanka. It thrives in most tropical and subtropical regions of India. Different parts of the plant contain various proteins, carbohydrates, sugars (arabinose, galactose, mannose, xylose, rhamnose, and glucuronic acid), minerals (magnesium and calcium salts of ghattic acid), and a wide range of phytochemicals such as alkaloids, flavonoids, phenols, terpenoids, sterols, saponins, tannins, coumarins, quinine, and ellagic acid. Studies have indicated the potential of Anogeissus latifolia in managing various health conditions, including antimicrobial, anti-inflammatory, anti-diabetic, anti-parasitic, antioxidant, hepatoprotective, wound healing, and hypolipidemic effects. However, like many medicinal plants, Anogeissus latifolia demonstrates a dose-dependent toxicity profile, particularly when administered intraperitoneally. Research efforts have been directed towards elucidating its safety profile, and findings suggest that it can be considered safe when administered within prescribed dosages. This paper aims to provide a comprehensive review encompassing the ethnobotanical significance, morphological characteristics, phytochemistry, pharmacological actions, and toxicological aspects of Anogeissus latifolia. Additionally, it explores future research perspectives in the field of Anogeissus latifolia pharmacology and therapeutics.
阔叶香须树，通常被称为轴木、印度胶树或加蒂胶树，属于使君子科，原产于印度、尼泊尔、缅甸和斯里兰卡。它在印度的大多数热带和亚热带地区生长旺盛。该植物的不同部位含有多种蛋白质、碳水化合物、糖类（阿拉伯糖、半乳糖、甘露糖、木糖、鼠李糖和葡萄糖醛酸）、矿物质（加蒂酸的镁盐和钙盐）以及多种植物化学物质，如生物碱、黄酮类化合物、酚类、萜类、甾醇、皂苷、单宁、香豆素、奎宁和鞣花酸。研究表明，阔叶香须树在治疗各种健康状况方面具有潜力，包括抗菌、抗炎、抗糖尿病、抗寄生虫、抗氧化、保肝、伤口愈合和降血脂作用。然而，与许多药用植物一样，阔叶香须树表现出剂量依赖性毒性特征，尤其是腹腔注射时。研究工作一直致力于阐明其安全性，研究结果表明，在规定剂量内给药时可认为是安全的。本文旨在全面综述阔叶香须树的民族植物学意义、形态特征、植物化学、药理作用和毒理学方面。此外，还探讨了阔叶香须树药理学和治疗学领域的未来研究前景。
