Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ibadan, Oduduwa Road, Ibadan 200132, Oyo State, Nigeria; Centre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Faculty of Science, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, United Kingdom; Department of Pharmaceutical and Medicinal Chemistry, College of Pharmacy, Afe Babalola University, Km 8.5, Afe Babalola Way, P.M.B. 5454, Ado-Ekiti, Ekiti State, Nigeria.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ibadan, Oduduwa Road, Ibadan 200132, Oyo State, Nigeria.
Fitoterapia. 2024 Jul;176:105979. doi: 10.1016/j.fitote.2024.105979. Epub 2024 Apr 29.
Anogeissus leiocarpus (DC.) Guill. & Perr. belongs to the family Combretaceae and is used both by African traditional medical practitioners and livestock rearers to treat diseases such as African trypanosomiasis, animal diarrhoea, asthma, cancer, cough, diabetes, dysentery, erectile dysfunction, fever, giardiasis, helminthiases, meningitis, menstrual disorders, monkeypox, oral infections, poliomyelitis, sickle cell anaemia, snake bites, toothache, urinary schistosomiasis, and yellow fever. Some of these activities have been associated with the presence of polyphenols in the plant which include ellagic acid derivatives, flavonoids, stilbenes, tannins, and triterpenes. Several bioactive molecules have been identified from A. leiocarpus. These include the main active constituents, ellagitannins, ellagic acid derivates, flavonoids and triterpenes. Pharmacological studies have confirmed its antibacterial, antifungal, antihyperglycemic, antihypertensive, antimalarial, antioxidative, antiparasitic, antitumour and anti-ulcer effects. The stem bark has been investigated mainly for biological activities and phytochemistry, and it is the most mentioned plant part highlighted by the traditional users in ethnomedicinal surveys. In vitro and in vivo models, which revealed a wide range of pharmacological actions against parasites causing helminthiasis, leishmaniasis, malaria and trypanosomiasis, have been used to study compounds from A. leiocarpus. Because of its uses in African traditional medicine and veterinary practices, A. leiocarpus has received considerable attention from researchers. The current review provides a comprehensive overview and critical appraisal of scientific reports on A. leiocarpus, covering its traditional uses, pharmacological activities and phytochemistry.
厚叶算盘子（DC.）Guill. & Perr. 属于使君子科，被非洲传统医学从业者和家畜饲养者用于治疗非洲锥虫病、动物腹泻、哮喘、癌症、咳嗽、糖尿病、痢疾、勃起功能障碍、发烧、贾第虫病、寄生虫病、脑膜炎、月经失调、猴痘、口腔感染、脊髓灰质炎、镰状细胞贫血、蛇咬伤、牙痛、尿路血吸虫病和黄热病等疾病。这些活动中的一些与植物中存在的多酚有关，包括鞣花酸衍生物、类黄酮、芪类、单宁和三萜类。已经从厚叶算盘子中鉴定出几种生物活性分子。其中包括主要活性成分，鞣花单宁、鞣花酸衍生物、类黄酮和三萜类。药理研究证实了其具有抗菌、抗真菌、降血糖、降压、抗疟、抗氧化、抗寄生虫、抗肿瘤和抗溃疡作用。茎皮主要用于研究生物活性和植物化学，并且是传统使用者在民族医学调查中突出强调的最常见植物部分。体外和体内模型揭示了针对引起蠕虫病、利什曼病、疟疾和锥虫病的寄生虫的广泛的药理作用，用于研究来自厚叶算盘子的化合物。由于其在非洲传统医学和兽医实践中的用途，厚叶算盘子受到了研究人员的广泛关注。本综述提供了对厚叶算盘子的科学报告的全面概述和批判性评估，涵盖了其传统用途、药理活性和植物化学。
